OXYGEN, GLUCOSE, AND LACTATE UPTAKE BY FETUS AND PLACENTA DURING PROLONGED HYPOXEMIA
OXYGEN, GLUCOSE, AND LACTATE UPTAKE BY FETUS AND PLACENTA DURING PROLONGED HYPOXEMIA
复制标题
DOI：
10.1152/ajpregu.1995.268.2.r303
复制
发表时间：
1995-02-01
影响因子：
2.8
通讯作者：
HARDING, R
中科院分区：
文献类型：
--
作者：
HOOPER, SB;WALKER, DW;HARDING, R
Our aim was to compare the effects of short (4 h) and prolonged (24 h) periods of reduced uterine blood flow (RUBF) on fetal and placental uptake of O-2, glucose, and lactate. In pregnant sheep, uterine and umbilical blood flows were measured under normal conditions and after 4 and 24 h of RUBF. A 50% reduction in uterine blood flow caused a 56% reduction in fetal arterial O-2 saturation (Sa(O2)). Umbilical blood flow increased from 325 +/- 33 to 378 +/- 32 ml.min(-1).kg(-1) (P < 0.05) after 4 h but was not different from pre-RUBF values after 24 h. O-2 uptake by the gravid uterus was not altered by RUBF, due to an increase (84%) in uterine O-2 extraction. Similarly, uteroplacental and fetal O-2 consumptions and fetal glucose uptake were not affected by RUBF, whereas uteroplacental glucose uptake was significantly reduced after 4 h (by 42%) and 24 h (by 58%) of RUBF. Fetal lactate uptake was greatly reduced from 78.7 +/- 15.5 to -167 +/- 57 mu mol.min(-1).kg(-1) after 4 h and to -198 +/- 80 mu mol.min(-1).kg(-1) after 24 h of RUBF; negative values indicate placental lactate uptake from the fetal circulation. Thus, although RUBF significantly reduced fetal Sa(O2), fetal and uteroplacental O-2 consumptions did not change. In addition, although fetal glucose uptake was not altered by RUBF, during RUBF the placenta became a major site of lactate clearance from the fetal circulation.
