The effects of prolonged ketamine-xylazine intravenous infusion on arterial blood pH, blood gases, mean arterial blood pressure, heart and respiratory rates, rectal temperature and reflexes in the rabbit.
The effects of prolonged ketamine-xylazine intravenous infusion on arterial blood pH, blood gases, mean arterial blood pressure, heart and respiratory rates, rectal temperature and reflexes in the rabbit.
复制标题
延长氯胺酮-甲苯噻嗪静脉输注对兔动脉血 pH 值、血气、平均动脉血压、心率和呼吸频率、直肠温度和反射的影响。
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Richardson Me
中科院分区：
文献类型：
--
作者：
J. Wyatt;Scott Ra;Richardson Me
家兔全身麻醉常用注射药物的长期和安全维持是困难的。长期、稳定的麻醉，恢复时间短，在人类使用连续静脉输注氯胺酮与或不使用镇静剂、肌肉松弛剂和麻痹剂。本研究评价了氯胺酮-噻嗪静脉滴注对新西兰大白兔的麻醉效果以及对呼吸和心血管的影响。采用盐酸氯胺酮（35 mg/kg）和盐酸噻嗪（5 mg/kg）分别麻醉10只雌性家兔，记录动脉血pO2、pCO2、pH基线值及心率和呼吸频率。在肌注给药后10分钟和4小时内监测上述参数以及平均动脉血压、翻正、眼睑、足部和下颌反射。结果显示，肌内诱导给药后10分钟出现中度低血压（与正常相差21.2%,p < 0.008）和深度低氧血症（与基线相差45%，p < 0.001）。开始氯胺酮（1 mg/min）和噻嗪（0.1 mg/min）输注4 h。低血压加重（与正常相差49.1%,p < 0.008），但低氧血症和高血糖逐渐改善，动脉ph无明显变化（p > 0.1）。呼吸频率无明显变化（p > 0.1），但呼吸质量不同。平均动脉pO2和pCO2值在输注完成后20分钟内恢复到基线水平。试验期间心率和直肠温度保持稳定。在整个研究过程中，所有家兔的翻正反射都被消除。（摘要删节250字）
The prolonged and safe maintenance of general anesthesia in rabbits with commonly used injectable agents is difficult. Protracted, stable anesthesia with short recovery time has been described in humans using continuous intravenous infusion of ketamine with or without sedatives, muscle relaxants and paralytics. This study evaluated the anesthetic plane achieved and respiratory and cardiovascular effects produced with a ketamine-xylazine intravenous infusion in New Zealand White rabbits. Ten female rabbits were anesthetized with intramuscularly administered ketamine hydrochloride (35 mg/kg) and xylazine hydrochloride (5 mg/kg) after the preanesthetic, baseline measurements of arterial blood pO2, pCO2 and pH and heart and respiratory rates were recorded. The above parameters as well as mean arterial blood pressure, righting, palpebral, pedal, and jaw reflexes were monitored ten minutes after the intramuscularly administered dosage and throughout 4 hours of infusion. Results showed moderate hypotension (21.2% deviation from normal, p less than 0.008) and profound hypoxemia (45% deviation from baseline, p less than 0.001) 10 minutes after the intramuscularly administered induction dosage. Then, the 4 hour infusion of ketamine (1 mg/minute) and xylazine (0.1 mg/minute) was started. Hypotension progressed (49.1% deviation from normal, p less than 0.008), but hypoxemia and hypercarbemia gradually improved with no resultant change (p greater than 0.1) in arterial pH. There was no significant change (p greater than 0.1) in respiratory rate but varying qualities of respiration were observed. Both mean arterial pO2 and pCO2 values returned to baseline within 20 minutes after completion of infusion. Heart rate and rectal temperature remained stable during the trial. The righting reflex was abolished in all rabbits throughout the study.(ABSTRACT TRUNCATED AT 250 WORDS)