Impact of human immunodeficiency virus and CD4 count on tuberculosis diagnosis: analysis of city-wide data from Cape Town, South Africa
Impact of human immunodeficiency virus and CD4 count on tuberculosis diagnosis: analysis of city-wide data from Cape Town, South Africa
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DOI：
10.5588/ijtld.13.0032
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发表时间：
2013-08-01
影响因子：
4
通讯作者：
Wood, R.
中科院分区：
文献类型：
--
作者：
Gupta, R. K.;Lawn, S. D.;Wood, R.
背景：人类免疫缺陷病毒(HIV)感染和CD4细胞计数对结核病(TB)诊断的影响尚未完全明确。目的：了解在常规规划条件下，HIV感染和CD4细胞计数对结核病病例的发病部位、痰涂片状况和总体实验室确认率(痰涂片镜检或培养)的影响。设计：对南非开普敦2009年电子结核病登记进行回顾分析。结果：在2009年报告的29 478例结核病病例中，25 744例(87.3%)已知HIV状态，其中13 237例(51.4%)为HIV阳性。其中，61.2%的人CD_4细胞计数为500个/亩，L，提示HIV血清转换后的早期影响。
BACKGROUND: The impact of human immunodeficiency virus (HIV) infection and CD4 count on the diagnosis of tuberculosis (TB) at population level is incompletely defined.OBJECTIVE: To determine how HIV infection and CD4 count affect disease site, sputum smear status and overall rate of laboratory confirmation (sputum smear microscopy or culture) of TB cases under routine programme conditions.DESIGN: Retrospective analysis of the 2009 electronic TB register for Cape Town, South Africa.RESULTS: Of 29 478 TB cases notified in 2009, HIV status was known for 25 744 (87.3%) cases, of whom 13 237 (51.4%) were HIV-positive. Of these, 61.2% had CD4 cell counts of 500 cells/mu l, suggesting early impact after HIV seroconversion.