Convergent methods assessing bone growth in an experimental model at dental implants in the minipig
Convergent methods assessing bone growth in an experimental model at dental implants in the minipig
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DOI：
10.1016/j.aanat.2014.02.001
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发表时间：
2014-01-01
影响因子：
2.2
通讯作者：
Dard, Michel
中科院分区：
文献类型：
--
作者：
Friedmann, Anton;Friedmann, Asisa;Dard, Michel
种植体牙科证明了其在成功治疗越来越多的具有亲水性（modSLA）或非亲水性（SLA）表面的牙科种植体的患者中的可靠性。这项小型猪研究的目的包括评估骨再生在两种类型的牙种植体在一个新的实验模型（侧骨缺损），通过实施一个收敛的分析方法相结合的组织学和接触radiography.In六个成年雌性小型猪标准化急性牙槽骨缺损创建，然后接受两个种植体在下颌骨两侧（modSLA和SLA，每一个结合引导骨再生）。愈合28天后处死动物。对中嵴样本进行分析，评估缺失的BIC至种植体肩关节（fBIC）;种植体表面上的垂直骨生长、骨：组织比和GBR部位材料残留物占据的移植材料面积。比较了从两种分析中获得的值，并仔细检查了统计相关性。尽管影像学方法给出的平均差异和调整平均值的维度低于组织学方法，但不同植入物的比较产生了相似的结果，用于评估影像学测量方法的相关性和一致性系数的统计分析显示fBIC具有高度一致性（一致性系数= 0.912，相关系数=0.939）。对于垂直新骨和移植物残留，观察到类似的结果。新骨和矿化组织的不一致性导致一致系数为0.182和0.054。结果表明，接触X射线可用于有关缺损填充的形态学评估;然而，如果需要更高的分辨率来区分组织中的定性差异，组织学染色仍然是有益的。(C)2014 Elsevier GmbH. All rights reserved.
Implant dentistry demonstrated its reliability in treating successfully an increased amount of patients with dental implants exhibiting hydrophilic (modSLA) or non-hydrophilic (SLA) surfaces. Objectives of this minipig study consisted in assessing bone regeneration at both types of dental implants in a new experimental model (lateral bone defects) by implementing a convergent analysis approach combining histology and contact radiography.In six adult female minipigs standardized acute alveolar defects were created, then receiving two implants in the mandibles bilaterally (modSLA and SLA, one of each combined with Guided Bone Regeneration). Animals were sacrificed after 28 days of healing. Mid-crestal specimen were analyzed assessing missing BIC to implant shoulder (fBIC); vertical bone growth upon implant surface, bone:tissue ratio and grafting material area occupied by material remnants for GBR sites. Values obtained from both analyses were compared and statistical correlations scrutinized. Although dimensions of mean differences and adjusted means given by radiographic method were lower than histological ones, comparison of different implants yielded similar results.Statistical analyses of correlation and concordance coefficients used to evaluate radiological method of measurement showed high level of concordance (concordance coefficient = 0.912 and correlation coefficient =0.939) for fBIC. Similar results were observed for vertical new bone and for remnants of graft. Discrepancies for new bone and for mineralized tissue resulted in concordance coefficient of 0.182 and 0.054.The results indicate that contact X-rays can be used for morphometric assessments regarding defect fill; however, histological staining remains beneficial if greater resolution for distinguishing qualitative differences in the tissues is required. (C) 2014 Elsevier GmbH. All rights reserved.