Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder
Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder
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DOI：
10.1016/j.pbb.2006.02.018
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发表时间：
2006-03-01
影响因子：
3.6
通讯作者：
Oosting, Ronald S.
中科院分区：
文献类型：
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作者：
van den Bergh, Filip S.;Bloemarts, Emilie;Oosting, Ronald S.
自发性高血压大鼠(SIR)作为注意缺陷多动障碍(ADHD)模型的有效性是通过比较自发性高血压大鼠(SHR)与Wistar-京都(WKY)大鼠和Wistar大鼠(Wistar)在不同测试中的有效性。在野外，SHR与Wistar和WKY相比都是过度活跃的，但仅在特定年龄段。在这些年龄段，哌醋甲酯(1 mg/kg)并不能减轻多动症。随后，在低速反应(DRL)-72S和五选择系列反应时间试验(5-CSRTT)的差异强化中进行了哌醋甲酯(0.1-10 mg/kg)的量效关系研究。与WKY而不是Wistar大鼠相比，SHR在DRL-72上的表现更差。醋酸甲酯(0.1-1.0 mg/kg)不能改善小鼠的生产性能。在5-CSRTT中，所有品系的大鼠的注意表现相似，但Wistar大鼠比SHR产生更多的冲动反应，而WKY哌醋甲酯只减弱了Wistar大鼠的冲动性。由于SHR在不同的试验中并不一致地表现出ADHD的症状，并且在WKY和Wistar大鼠中都观察到了哌醋甲酯的作用，但在SIR中没有观察到，因此我们得出结论：SHR不是ADHD的代表性动物模型。(C)2006 Elsevier Inc.保留所有权利
The validity of the Spontaneously Hypertensive rat (SIR) as a model for Attention Deficit Hyperactivity Disorder (ADHD) is explored by comparing the SHR with Wistar-Kyoto (WKY) and Wistar rats in a number of different tests. In the open field, SHR are hyperactive compared to both Wistar and WKY, but only at specific ages. At those ages, methylphenidate (1 mg/kg) did not attenuate hyperactivity. Subsequently, a dose response study of methylphenidate (0.1-10 mg/kg) was conducted in the Differential Reinforcement of Low-rate responding (DRL)-72s and five-choice serial reaction time tests (5-CSRTT). Compared to WKY but not Wistar rats, SHR performed worse on the DRL-72s. Performance was not improved by methylphenidate (0.1-1.0 mg/kg). In the 5-CSRTT, attentional performance was similar for all rat strains, but Wistar rats made more impulsive responses than both the SHR and the WKY Methylphenidate only attenuated impulsivity in Wistar rats. Because SHR do not consistently display symptoms of ADHD across the different tests, and methylphenidate effects were observed in both WKY and Wistar rats, but not in SIR, we conclude that SHR is not a representative animal model for ADHD. (c) 2006 Elsevier Inc. All rights reserved