Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older
Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older
复制标题
DOI：
10.1136/jnnp.74.6.720
复制
发表时间：
2003-06-01
影响因子：
11
通讯作者：
Sulkava, R
中科院分区：
文献类型：
--
作者：
Rahkonen, T;Eloniemi-Sulkava, U;Sulkava, R
目的：根据共识标准估计路易体痴呆（DLB）在75岁及以上普通人群中的患病率。方法：“Kuopio 75+研究”是一项以人群为基础的健康调查，主要研究75岁及以上老年人痴呆的临床流行病学和功能能力。1998年1月1日，从芬兰东北部库奥皮奥市1923年1月1日前出生的总人口中随机抽取了700名受试者（n = 4518）。研究对象接受了结构化访谈和临床检查。结果：共检查老年受试者601例（占随机抽样的86%）。137名患者被诊断患有痴呆症，患病率为22.8%（95%可信区间为19.4%至26.2%）。DLB患病率为5.0%(3.2% ~ 6.7%)，占所有痴呆受试者的22%。20例被诊断为可能的DLB(3.3%(1.9% ~ 4.8%))， 10例被诊断为可能的DLB（1.7%(0.6% ~ 2.7%)）。阿尔茨海默病的患病率为10.6%（占所有痴呆受试者的47%），血管性痴呆的患病率为5.3%(23%)，其他类型痴呆疾病的患病率为1.8%（8%）。结论：在75岁及以上的普通人群中，符合DLB诊断标准的疾病患病率是阿尔茨海默病的一半，与血管性痴呆相同。
Objective: To estimate the prevalence of dementia with Lewy bodies (DLB) according to the consensus criteria in a general population aged 75 years or older.Methods: The "Kuopio 75+ study" is a population based health survey focused on the clinical epidemiology of dementia and functional capacity among elderly subjects aged 75 years or older. On 1 January 1998, a random sample of 700 subjects was drawn from a total population born before 1 January 1923, living in the city of Kuopio, northeast Finland (n = 4518). The study subjects underwent a structured interview and clinical examination.Results: 601 elderly subjects (86% of the random sample) were examined. A dementia disorder was diagnosed in 137-a prevalence of 22.8% (95% confidence interval 19.4% to 26.2%). The prevalence of DLB was 5.0% (3.2% to 6.7%), comprising 22% of all demented subjects. Probable DLB was diagnosed in 20 subjects (3.3% (1.9% to 4.8%)), and possible DLB in 10 (1.7% (0.6% to 2.7%)). The prevalence of Alzheimer's disease was 10.6% (47% of all demented subjects), of vascular dementia, 5.3% (23%), and of other types of dementing disorders, 1.8% (8%).Conclusions: In a general population aged 75 years and older, the prevalence of a disorder fulfilling the diagnostic criteria of DLB is half that of Alzheimer's disease and the same as for vascular dementia.