Histopathology of non‐scarring alopecia
Histopathology of non‐scarring alopecia
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非疤痕性脱发的组织病理学
DOI：
10.1111/j.1600-0560.1995.tb01391.x
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发表时间：
1995
影响因子：
1.7
通讯作者：
G. Lupton
中科院分区：
文献类型：
--
作者：
L. Sperling;G. Lupton
关于非密封性灵长类动物组织病理学特征的loett.ses。由此导致的脱发会导致头发的分散，从而使头发变得脆弱和断裂。毛干疾病的诊断主要是通过检查脱落的毛干，很少进行组织病理学检查。研究脱发的原因是头发被自由基所取代。脱发的毛发通常是可逆的，通常是由一种先天性脱发引起的。第一种是休止期脱发，在这种情况下，毛发的正常脱落更多地进入休止期阶段，从而抑制了休止期毛发的过度脱落。一个典型的例子是，一个受影响的妇女在分娩三个月后出现产后抑郁症。脱发的主要原因是生长期毛发生长抑制剂（也称为生长期毛发生长抑制剂），它被活跃生长期毛发的代谢机制中的异常细胞所吸收。这会导致生长期毛发的脱落。生长期脱发的典型例子是在化疗或去甲肾上腺素治疗后脱发。在许多情况下，瘢痕性脱发，过度脱落的两个，休止期头发和生长期头发occttrs，bhirring之间的区别休止期ellltivium和生长期ellltivitnn。
The lollowitig disett.s.sion loett.ses on llie histopathologic iitiditigs in non-seaiiing lorm.s of alopeeia. Exehided IVom this clisenssion ate Ibrtns ol hair loss resulting IVom dist)rders of the hair shalt, whieh eattse hair fragility atid breakage. Hair shaft disoi ders are tistially diagnosed by examination ol elipped hair shalts, and histopalhologie examination is seldom pursued. Searritig alopeeia resttlts in pertnanent hair loss as fbllieles are destroyed at:id replaced by libroits lissvte. Eoss of hair in noti-searring alopeeia is often reversible, atid usually oeeurs by one of IVnnmeehanistiis. The first is telogen effltivitim, in whieh greater that normal ntttiibeis of hairs are preeipitated into the telogen phase, restrltitig iti excessive shedding of telogen hairs. A classic example is post-partuni telogeti efllrtviutii, oecurritig abcntt three months after ati affeeted woman delivers a haby. The seeotid tnechatiism for hair loss is anagen elTlttvitim (also called anagen delltivinm), eatised by an abrnpt hall in ihe metabolic machinery of actively gixnving anagen hairs. This lestilts in the shedding ol tiumerous abnormal ("dystrophic") anagen hairs. The classic example ol anagen eflluvium is hair loss alter raclialion therapy or chemotherapy. In many cases of tion-scarring alopecia, excessive shedding of both, telogen hairs and anagen hairs occttrs, bhirring the distinction between telogen el'lltivium and anagen ellltivitnn.