Indole-3-Carbinol Selectively Prevents Chronic Stress-Induced Depression-but not Anxiety-Like Behaviors via Suppressing Pro-Inflammatory Cytokine Production and Oxido-Nitrosative Stress in the Brain.
Indole-3-Carbinol Selectively Prevents Chronic Stress-Induced Depression-but not Anxiety-Like Behaviors via Suppressing Pro-Inflammatory Cytokine Production and Oxido-Nitrosative Stress in the Brain.
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Indole-3-Carbinol 通过抑制大脑中促炎性细胞因子的产生和氧化亚硝化应激来选择性地预防慢性压力引起的抑郁，但不能预防焦虑样行为
DOI：
10.3389/fphar.2022.829966
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发表时间：
2022
影响因子：
5.6
通讯作者：
Huang C
中科院分区：
文献类型：
--
作者：
Pan S;Ma Y;Yang R;Lu X;You Q;Ye T;Huang C
吲哚-3-甲醇（I3C）是十字花科蔬菜中富含的一种植物化学物质，具有抗氧化应激、抗炎症、抗癌等多种生物活性。在本研究中，我们研究了I3C对小鼠慢性应激性行为异常的调节作用。结果表明，10、30和60 mg/kg剂量的I3C重复治疗可预防小鼠慢性社会失败应激（CSDS）诱导的悬尾试验、强迫游泳试验、蔗糖偏好试验和社会互动试验中的行为异常，而对CSDS诱导的升高加迷宫、光暗试验和空地试验中的行为异常无影响。这表明I3C治疗可以选择性地防止长期应激小鼠出现抑郁，但不能防止焦虑样行为。进一步分析表明，重复I3C治疗（60 mg/kg， 10天）可阻止csds诱导的白介素-1β (IL-1β)、IL-6和肿瘤坏死因子-α (TNF-α) mRNA和蛋白水平的升高，但不影响csds诱导的海马和前额叶皮层IL-4、IL-10和y -1 mRNA和/或蛋白水平的降低，表明I3C可以选择性地预防大脑慢性应激诱导的促炎反应，而非抗炎反应。进一步分析表明，重复I3C治疗（60 mg/kg, 10 d）可阻止csds诱导的海马和前额叶皮层亚硝酸盐和丙二醛（MDA）水平升高、谷胱甘肽（GSH）含量降低和脑源性神经营养因子（BDNF）蛋白水平降低。这些结果表明，I3C可能通过抑制大脑中的神经炎症和氧化亚硝化应激，选择性地阻止小鼠慢性应激诱导的抑郁样行为。
Indole-3-carbinol (I3C), a phytochemical enriched in most cruciferous vegetables, has been shown to display various biological activities such as anti-oxidative stress, anti-inflammation, and anti-carcinogenesis. In this study, we investigated the regulatory effect of I3C on chronic stress-induced behavioral abnormalities in mice. Results showed that repeated I3C treatment at the dose of 10, 30, and 60 mg/kg prevented chronic social defeat stress (CSDS)-induced behavioral abnormalities in the tail suspension test, forced swimming test, sucrose preference test, and social interaction test in mice, and did not affect CSDS-induced behavioral abnormalities in the elevated plus maze, light-dark test, and open-field test, suggesting that the I3C treatment selectively prevents the onset of depression- but not anxiety-like behaviors in chronically stressed mice. Further analysis demonstrated that repeated I3C treatment (60 mg/kg, 10 days) prevented CSDS-induced increases in levels of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) mRNA and protein, but did not affect CSDS-induced decreases in levels of IL-4, IL-10, and Ym-1 mRNA and/or protein in the hippocampus and prefrontal cortex, suggesting that I3C can selectively prevent chronic stress-induced pro-inflammatory but not anti-inflammatory responses in the brain. Further analysis showed that repeated I3C treatment (60 mg/kg, 10 days) prevented CSDS-induced increases in levels of nitrite and malondialdehyde (MDA), decreases in contents of glutathione (GSH), and decreases in levels of brain derived neurotrophic factor (BDNF) protein in the hippocampus and prefrontal cortex. These results demonstrated that I3C selectively prevents chronic stress-induced depression-like behaviors in mice likely through suppressing neuroinflammation and oxido-nitrosative stress in the brain.
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影响因子：
4.3
作者：
Li Z;Li Z;Lv X;Li Z;Xiong L;Hu X;Qin D
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DOI：
10.1093/ijnp/pyx009
发表时间：
2017-06-01
期刊：
The international journal of neuropsychopharmacology
影响因子：
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通讯作者：
Huang C
DOI：
10.1007/7854_2021_294
发表时间：
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期刊：
ANHEDONIA
影响因子：
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作者：
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影响因子：
3.1
作者：
Cheng, Li;Huang, Chao;Chen, Zhuo
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影响因子：
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作者：
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通讯作者：
Langmann T