High Pretreatment Mean Corpuscular Volume Can Predict Worse Prognosis in Patients With Esophageal Squamous Cell Carcinoma who Have Undergone Curative Esophagectomy: A Retrospective Multicenter Cohort Study.
High Pretreatment Mean Corpuscular Volume Can Predict Worse Prognosis in Patients With Esophageal Squamous Cell Carcinoma who Have Undergone Curative Esophagectomy: A Retrospective Multicenter Cohort Study.
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DOI：
10.1097/as9.0000000000000165
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发表时间：
2022-06
期刊：
影响因子：
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通讯作者：
Baba, Hideo
中科院分区：
文献类型：
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作者：
Yoshida, Naoya;Sasaki, Ken;Kanetaka, Kengo;Kimura, Yasue;Shibata, Tomotaka;Ikenoue, Makoto;Nakashima, Yuichiro;Sadanaga, Noriaki;Eto, Kojiro;Tsuruda, Yusuke;Kobayashi, Shinichiro;Nakanoko, Tomonori;Suzuki, Kosuke;Takeno, Shinsuke;Yamamoto, Manabu;Morita, Masaru;Toh, Yasushi;Baba, Hideo
探讨平均红细胞体积（MCV）对食管鳞癌患者术后预后的预测价值。MCV在高酒精和烟草消费的患者中增加。这样的生活方式可能是营养不良、与这些习惯相关的合并症和多种原发性恶性肿瘤的风险因素，这些可能与术后频繁发病和预后不良有关。这项研究包括了1673名ESCC患者，他们在2005年4月至2020年11月期间在八个研究所接受了根治性食管切除术。根据治疗前MCV的标准值将患者分为正常组和高MCV组。回顾性比较两组的临床背景、短期结果和预后。总体而言，26.9%的患者MCV较高，这与男性、习惯性吸烟和饮酒、多原发恶性肿瘤和营养不良显著相关，如通过体重指数、血红蛋白和血清白蛋白值以及老年营养风险指数估计的。术后呼吸系统疾病（P = 0.0075）常发生在高MCV组。高MCV是总生存率（风险比，1.27; 95%可信区间，1.049-1.533; P = 0.014）和无复发生存率（风险比，1.23; 95%可信区间，1.047-1.455; P = 0.012）较差的独立预后因素。高MCV与习惯性饮酒和吸烟、营养不良和多种原发性恶性肿瘤相关，可能是接受食管切除术的ESCC患者短期和长期预后较差的替代标志物。迷你摘要：这项多中心队列研究阐明，治疗前平均红细胞体积较高与习惯性饮酒和吸烟、营养不良和多种原发性恶性肿瘤相关，可能是接受根治性食管切除术的食管鳞状细胞癌患者短期和长期结局较差的替代标志物。
To establish the prognostic value of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who have undergone esophagectomy. The MCV increases in patients with high alcohol and tobacco consumption. Such a lifestyle can be a risk factor for malnutrition, comorbidities related to those habits, and multiple primary malignancies, which may be associated with frequent postoperative morbidity and poor prognosis. This study included 1673 patients with ESCC who underwent curative esophagectomy at eight institutes between April 2005 and November 2020. Patients were divided into normal and high MCV groups according to the standard value of their pretreatment MCV. Clinical background, short-term outcomes, and prognosis were retrospectively compared between the groups. Overall, 26.9% of patients had a high MCV, which was significantly associated with male sex, habitual smoking and drinking, multiple primary malignancies, and malnutrition, as estimated by the body mass index, hemoglobin and serum albumin values, and the Geriatric Nutritional Risk Index. Postoperative respiratory morbidity (P = 0.0075) frequently occurred in the high MCV group. A high MCV was an independent prognostic factor for worse overall survival (hazard ratio, 1.27; 95% confidence interval, 1.049–1.533; P = 0.014) and relapse-free survival (hazard ratio, 1.23; 95% confidence interval, 1.047–1.455; P = 0.012). A high MCV correlates with habitual drinking and smoking, malnutrition, and multiple primary malignancies and could be a surrogate marker of worse short-term and long-term outcomes in patients with ESCC who undergo esophagectomy. Mini-Abstract: This multicenter cohort study elucidated that a high pretreatment mean corpuscular volume correlated with habitual drinking and smoking, malnutrition, and multiple primary malignancies, and could be a surrogate marker of worse short-term and long-term outcomes in patients with esophageal squamous cell carcinoma who have undergone curative esophagectomy.