SYNTHESIS OF SIDE-CHAIN FUNCTIONALIZED AMINO-ACID DERIVATIVES THROUGH REACTION OF ALKYL NITRONATES WITH ALPHA-BROMOGLYCINE DERIVATIVES
SYNTHESIS OF SIDE-CHAIN FUNCTIONALIZED AMINO-ACID DERIVATIVES THROUGH REACTION OF ALKYL NITRONATES WITH ALPHA-BROMOGLYCINE DERIVATIVES
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DOI：
10.1016/0040-4020(95)00398-r
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发表时间：
1995-07-10
期刊：
影响因子：
2.1
通讯作者：
TIEKINK, ERT
中科院分区：
文献类型：
--
作者：
EASTON, CJ;ROSELT, PD;TIEKINK, ERT
烷基硝酸酯与α-溴甘氨酸衍生物的反应提供了各种卤代、β-硝基和α，β-脱氢-α-氨基酸衍生物的途径，包括β-官能化的α，β-脱氢氨基酸衍生物。用这种方法也可以制备游离的β-硝基-α-氨基酸的盐酸盐。
Reactions of alkyl nitronates with alpha-bromoglycine derivatives provide access to a variety of halo-, beta-nitro- and alpha,beta-dehydro-alpha-amino acid derivatives, including beta-functionalized alpha,beta-dehydroamino acid derivatives. The hydrochloride salts of free beta-nitro-alpha-amino acids can also be prepared using this approach.