Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies.
Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies.
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DOI：
10.3324/haematol.2019.236000
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发表时间：
2020-09-01
期刊：
影响因子：
10.1
通讯作者：
Campo E
中科院分区：
文献类型：
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作者：
Delgado J;Nadeu F;Colomer D;Campo E
慢性淋巴细胞白血病是一种明确的淋巴肿瘤，具有非常异质性的生物学和临床行为。过去十年在新的发现方面取得了显著的成果，阐明了疾病发病机制的多个方面，包括遗传易感性机制，对驱动疾病的免疫遗传因素的相关性的见解，基因组改变的分析，表观遗传亚型，全球表观基因组肿瘤细胞重编程，肿瘤细胞和微环境相互作用的调节，以及从单克隆B细胞淋巴细胞增多的早期步骤到进展和转化为弥漫性大B细胞淋巴瘤的克隆进化动力学。所有这些知识都提供了新的视角，正在利用新的靶向药物和管理策略进行治疗。在这篇综述中，我们概述了这些新的进展，并强调了需要进一步进展的问题和观点，以将这些生物学知识转化为临床，并改善患者的预后。
Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very heterogeneous biological and clinical behavior. The last decade has been remarkably fruitful in novel findings, elucidating multiple aspects of the pathogenesis of the disease including mechanisms of genetic susceptibility, insights into the relevance of immunogenetic factors driving the disease, profiling of genomic alterations, epigenetic subtypes, global epigenomic tumor cell reprogramming, modulation of tumor cell and microenvironment interactions, and dynamics of clonal evolution from early steps in monoclonal B-cell lymphocytosis to progression and transformation into diffuse large B-cell lymphoma. All this knowledge has offered new perspectives that are being exploited therapeutically with novel, targeted agents and management strategies. In this review we provide an overview of these novel advances and highlight questions and perspectives that need further progress to translate this biological knowledge into the clinic and improve patients’ outcome.
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