Wnt Signaling Is Critical for Maladaptive Cardiac Hypertrophy and Accelerates Myocardial Remodeling
Wnt Signaling Is Critical for Maladaptive Cardiac Hypertrophy and Accelerates Myocardial Remodeling
复制标题
DOI：
10.1161/hypertensionaha.109.141127
复制
发表时间：
2010-04-01
期刊：
影响因子：
8.3
通讯作者：
Hardt, Stefan E.
中科院分区：
文献类型：
--
作者：
Malekar, Pratima;Hagenmueller, Marco;Hardt, Stefan E.
进化保守的Wnt信号通路调节心脏发生。然而，Wnt通路的成员也在成人心脏中表达。虽然Wnt信号在正常条件下是静止的，但我们注意到心脏病理性应激的激活，例如慢性后负荷增加。为了研究Wnt信号传导在出生后心脏中的作用，我们在心脏特异性过表达Dvl-1（Dvl-1-Tg）的转基因小鼠和培养的心肌细胞中修改了Wnt调节因子dishevelled 1（Dvl-1）的表达和功能。Dvl-1-Tg小鼠（3个月）有严重的心脏肥大（心脏重量：体重比：5.2 +/- 0.3 mg/g野生型[WT] vs 6.4 +/- 0.7 mg/g Dvl-1-Tg; P
The evolutionary conserved Wnt signaling pathway regulates cardiogenesis. However, members of the Wnt pathway are also expressed in the adult heart. Although Wnt-signaling is quiescent under normal conditions, we noticed activation on pathological stress of the heart, such as chronic afterload increase. To examine the role of Wnt signaling on the postnatal heart, we modified the expression and function of the Wnt regulator dishevelled 1 (Dvl-1) both in transgenic mice with cardiac-specific overexpression of Dvl-1 (Dvl-1-Tg) and in cultured cardiac myocytes. Dvl-1-Tg mice (3 months) had severe cardiac hypertrophy (heart weight: body weight ratio: 5.2 +/- 0.3 mg/g wild-type [WT] versus 6.4 +/- 0.7 mg/g Dvl-1-Tg; P