Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.
Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.
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DOI：
10.1016/j.jalz.2009.07.003
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Cabeza R
中科院分区：
文献类型：
--
作者：
Dennis NA;Browndyke JN;Stokes J;Need A;Burke JR;Welsh-Bohmer KA;Cabeza R
确定APOE e4等位基因是否在年轻成年人成功记忆编码过程中影响内侧颞叶（MTL）的功能激活和连接性。
24名健康的年轻成年人，其中12名是APOE e4等位基因携带者，12名是非携带者，在后续记忆范式中使用事件相关功能磁共振成像（fMRI）进行扫描。成功编码的神经解剖学相关性通过对随后记住的与忘记的任务项目的神经活动更强来衡量，简称为编码成功活动（ESA）。评估了MTL内ESA的组间差异以及与MTL的全脑功能连接性。
在没有人口统计学或行为表现差异的情况下，APOE e4等位基因携带者为了完成相同的编码任务，相对于非携带者表现出更强的双侧MTL活动。此外，虽然e4携带者显示出与编码成功活动相关的MTL活动与后扣带回（PCC）和其他边缘周围区域有更强的功能连接性，但在前部和后部皮质发现整体连接性降低。
这些结果表明，APOE e4等位基因可能不仅影响MTL内的功能激活，还影响MTL与记忆编码相关的其他区域的功能连接性。年轻成年e4携带者中MTL与PCC的功能连接性增强表明，在迟发性痴呆成为实际风险或需要考虑之前很久，APOE可能就在已知与阿尔茨海默病有关的脑区早期表达。也有可能这些功能连接性差异反映了APOE在早期发育过程中的多效性影响。
To determine if the APOE e4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTL) during successful memory encoding in young adults. Twenty-four healthy young adults, twelve carriers and twelve non-carriers of the APOE e4 allele, were scanned in a subsequent memory paradigm, using event-related functional magnetic resonance imaging (fMRI). The neuroanatomical correlates of successful encoding were measured as greater neural activity for subsequently remembered versus forgotten task items, or in short, encoding success activity (ESA). Group differences in ESA within the MTL, as well as whole brain functional connectivity with the MTL, were assessed. In the absence of demographic or performance differences, APOE e4 allele carriers exhibited greater bilateral MTL activity relative to the non-carriers to accomplish the same encoding task. Additionally, while e4 carriers demonstrated greater functional connectivity of ESA-related MTL activity with the posterior cingulate (PCC) and other peri-limbic regions, overall connectivity reductions were found across anterior and posterior cortices. These results suggest that the APOE e4 allele may influence not only functional activations within the MTL, but functional connectivity of the MTL to other regions implicated in memory encoding. Enhanced functional connectivity of the MTL with the PCC in young adult e4 carriers suggests that APOE may be expressed early in brain regions known to be involved in Alzheimer's disease long before late-onset dementia is a practical risk or consideration. It is also possible that these functional connectivity differences reflect pleiotropic effects of APOE during early development.
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影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
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DOI：
10.1073/pnas.2235925100
发表时间：
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影响因子：
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作者：
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