A NIR heptamethine dye with intrinsic cancer targeting, imaging and photosensitizing properties
A NIR heptamethine dye with intrinsic cancer targeting, imaging and photosensitizing properties
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一种近红外七次甲基染料，具有内在的癌症靶向、成像和光敏特性
DOI：
10.1016/j.biomaterials.2011.11.081
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发表时间：
2012-03-01
期刊：
影响因子：
14
通讯作者：
Shi, Chunmeng
中科院分区：
文献类型：
--
作者：
Tan, Xu;Luo, Shenglin;Shi, Chunmeng
未来的个性化肿瘤学显著依赖于多功能药物的开发，以整合肿瘤靶向，成像和细胞毒活性。在我们最近的研究中，我们最近发现了一种近红外荧光七甲川染料IR-780，在肿瘤细胞的广谱中具有意想不到的优先积累，用于体内肿瘤靶向和成像。在此基础上，我们合成了一种IR-780类似物IR-808，并对其生物学特性进行了研究。IR-808不仅具有与IR-780相似的肿瘤靶向和成像特性，而且具有独特的光依赖性细胞毒活性。此外，IR-808还具有良好的光学和药代动力学特性，以及良好的生物相容性。这种染料有望成为未来肿瘤靶向成像和光动力学治疗的候选多功能治疗诊断剂。(C)2011爱思唯尔有限公司保留所有权利。
The future personalized oncology significantly relies on the development of multifunctional agents to integrate tumor targeting, imaging, and cytotoxic activities. In our recent study, we have recently identified a near infrared fluorescent heptamethine dye, IR-780, with unexpected preferential accumulation in a broad spectra of tumor cells for in vivo tumor targeting and imaging. On the basis of this foregoing work, in this study, we describe here the chemical synthesis and biological characterization of an analog of IR-780, termed as IR-808, which not only possesses similar tumor targeting and imaging properties of IR-780, but also has unique photodependent cytotoxic activity. In addition, IR-808 also exhibits favorable optical and pharmacokinetic properties, as well as good biocompatibility. This dye may hold promise as a candidate multifunctional theranostic agent for future tumor targeted imaging and photodynamic therapy. (C) 2011 Elsevier Ltd. All rights reserved.