Plasma membrane Ca2+ pumps.
Plasma membrane Ca2+ pumps.
复制标题
质膜 Ca2 泵。
DOI：
10.1111/j.1749-6632.1997.tb52225.x
复制
发表时间：
1997
影响因子：
5.2
通讯作者：
Filoteo,AG
中科院分区：
文献类型：
--
作者：
Penniston,JT;Enyedi,A;Verma,AK;Adamo,HP;Filoteo,AG
Plasma membrane Ca2+ pumps are P-type ATPases and therefore are members of the same superfamily as the Na+, K+ ATF'ase and the sarcoplasmic reticulum Ca2+ pump. Like them, this pump moves a biologically essential ion up its concentration gradient at the expense of hydrolysis of ATP. The pump is important in shaping the Ca2+ signal that controls the biological responses of cells. When cells are simulated by agonists, Ca2+ flows into the cytosol through channels from either intracellular stores or outside the cell. Activation of these channels determines the rising phase of the Ca2+ signal, but the falling phase is controlled by the two Ca2+ pumps, those of the plasma membrane and the sarco/endoplasmic reticulum, and in some cells by the Na+/Ca2+ exchanger.
