HEAD-DIRECTION CELLS IN THE RAT POSTERIOR CORTEX .2. CONTRIBUTIONS OF VISUAL AND IDEOTHETIC INFORMATION TO THE DIRECTIONAL FIRING
HEAD-DIRECTION CELLS IN THE RAT POSTERIOR CORTEX .2. CONTRIBUTIONS OF VISUAL AND IDEOTHETIC INFORMATION TO THE DIRECTIONAL FIRING
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DOI：
10.1007/bf00243213
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发表时间：
1994-09-01
影响因子：
2
通讯作者：
MCNAUGHTON, BL
中科院分区：
文献类型：
--
作者：
CHEN, LL;LIN, LH;MCNAUGHTON, BL
本研究探讨了视觉和意识（a）线索对大鼠后皮质头向（HD）细胞空间调谐的影响。细胞外，单个单位的反应记录从动物执行两个不同的任务，一个空间工作记忆任务的径向臂迷宫和被动旋转任务的修改后的“懒惰苏珊”平台。视觉线索的影响进行了评估，通过操纵的位置，一个白色和三个黑色的提示卡放置在迷宫周围。我们发现三个主要类别的HD细胞的基础上，他们的反应线索操纵迷宫任务。A型细胞（10/41）随着线索的旋转而沿着它们的偏好方向旋转。大多数（B型，25/41）的HD细胞不受视觉线索的旋转，保持其既定的首选方向。C型细胞（6/41）表现出复杂的反应，提示旋转，与首选的方向反映要么A型和B型反应的组合或不可预测的反应。结果表明，内部表征的方向性可以校准的视觉线索，一些记忆过程可能已经参与了注册的先前的线索位置。在迷宫任务和被动旋转任务中测试了11个细胞。大多数（9/11）在前一个任务中表现出显着的方向性，但在后一个任务中没有或弱的方向性，这表明运动相关的ideothetic线索可能被用来支持这些细胞的定向放电。只有两个细胞在这两个任务中表现出显着的方向性。在迷宫任务中，他们建立的偏好方向并不沿着线索旋转，但在被动旋转任务中，他们确实会随着线索旋转。我们的结论是，在这些皮质HD细胞的方向调谐的动态方面可能代表在线校准的角坐标表示。
This study investigated the effects of visual and ideothetic(a) cues on the spatial tuning of head-direction (HD) cells recorded in the rat posterior cortices. Extracellular, single unit responses were recorded from animals performing each of two different tasks, a spatial working memory task on a radial-arm maze and a passive rotation task on a modified ''lazy Susan'' platform. The influence of visual cues was assessed by manipulating the position of one white and three black cue-cards placed around the maze. We found three major categories of HD cells based on their response to cue manipulations in the maze tasks. Type A cells (10/41) rotated their preferred directions along with the rotation of the cues. The majority (type B, 25/41) of the HD cells were unaffected by the rotation of visual cues, maintaining their established preferred direction. Type C cells (6/41) showed complex responses to cue rotation, with the preferred direction reflecting either a combination of both type A and type B responses or an unpredictable response. The results indicate that the internal representation of directionality can be calibrated by visual cues and that some mnemonic processes may have been involved in the registration of the previous cue locations. Eleven cells were tested in both the maze task and the passive rotation task. Most (9/11) showed a significant directionality in the former task, but showed either no or weak directionality in the latter task, suggesting that movement-related ideothetic cues may be used in supporting the directional firing of these cells. Only two cells showed significant directionality in both tasks. Their established preferred directions did not rotate along with the cues in the maze task, but did rotate with the cues in the passive rotation task. We conclude that the dynamic aspect of the directional tuning in these cortical HD cells may represent on-line calibration of an angular coordinate representation.