Deja vu all over again: Finding and analyzing protein structure similarities
Deja vu all over again: Finding and analyzing protein structure similarities
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DOI：
10.1016/j.str.2004.09.016
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发表时间：
2004-12-01
期刊：
影响因子：
5.7
通讯作者：
Kleywegt, GJ
中科院分区：
文献类型：
--
作者：
Sierk, ML;Kleywegt, GJ
结构比较是当今结构生物学的一个重要方面。随着新算法、相似性分数和统计分数的发展，结构比较领域正在迅速发展。通过高通量的努力，实验结构和结构模型的预测大幅增加意味着使用自动化方法进行结构比较和结构数据库搜索将变得越来越普遍。这篇文章旨在指导结构生物学家了解结构比对的基础知识，并提供可用软件工具的概述。其主要目的是鼓励用户获得一些了解的优势和结构对齐的局限性，并考虑到这些因素时，解释不同的程序的结果。
Structure comparison is a crucial aspect of structural biology today. The field of structure comparison is developing rapidly, with the development of new algorithms, similarity scores, and statistical scores. The predicted large increase of experimental structures and structural models made possible by high-throughput efforts means that structural comparison and searching of structural databases using automated methods will become increasingly common. This Ways & Means article is meant to guide the structural biologist in the basics of structural alignment, and to provide an overview of the available software tools. The main purpose is to encourage users to gain some understanding of the strengths and limitations of structural alignment, and to take these factors into account when interpreting the results of different programs.