Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones.
Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones.
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左旋多巴、安非他明和阿扑吗啡对大鼠多巴胺能神经元放电率的影响比较。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
R. Roth
中科院分区：
文献类型：
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作者：
B. Bunney;G. Aghajanian;R. Roth
我们已经报道，全身给药D-苯丙胺选择性地抑制大鼠中脑黑质致密带和邻近腹侧被盖区含有多巴胺的细胞的放电频率。D-苯丙胺的作用被认为是通过释放多巴胺并阻止其重新摄取，通过增加突触后受体位置2-4的多巴胺可获得性来刺激多巴胺受体。然后，增加的受体刺激被认为启动了对多巴胺单位的神经元反馈抑制。另有两种药物被认为可以刺激多巴胺受体：L-多巴被芳香氨基酸脱羧酶转化为多巴胺，增加了受体6-8处潜在的多巴胺含量，而阿朴吗啡似乎直接刺激受体9-11。由于据称有刺激多巴胺受体的能力，因此预测这些药物也会减缓多巴胺细胞10的速度。
WE have reported that systemically administered d-amphet-amine selectively depresses the firing rate of dopamine-containing cells in the substantia nigra zona compacta and adjacent ventral tegmental area of the rat midbrain1. d-Amphetamine is believed to act by releasing dopamine and blocking its re-uptake, leading to stimulation of dopamine receptors by increasing the availability of dopamine at postsynaptic receptor sites2–4. The increased receptor stimulation is then thought to initiate neuronal feedback inhibition of dopamine units5. Two other drugs are believed to stimulate dopamine receptors: L-dopa is converted to dopamine by an aromatic amino acid decarboxylase, increasing the amount of dopamine potentially available at receptor sites6–8, while apomorphine seems to stimulate the receptors directly9–11. Because of this alleged ability to stimulate dopamine receptors, it has been predicted that these drugs also slow dopamine cells10.