Kilo-voltage cone-beam computed tomography setup measurements for lung cancer patients; First clinical results and comparison with electronic portal-imaging device
Kilo-voltage cone-beam computed tomography setup measurements for lung cancer patients; First clinical results and comparison with electronic portal-imaging device
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DOI：
10.1016/j.ijrobp.2007.01.014
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发表时间：
2007-06-01
影响因子：
7
通讯作者：
Lebesque, Joos V.
中科院分区：
文献类型：
--
作者：
Borst, Gerben R.;Sonke, Jan-Jakob;Lebesque, Joos V.
目的：千伏锥束计算机断层扫描（CBCT）已被开发用于提供准确的软组织和骨骼设置信息。我们评估了临床CBCT设置数据和比较CBCT测量与电子门静脉成像设备（EPID）的图像为lung cancer patients.Methods和Materials：CBCT扫描在治疗单位相对于计划CT的设置错误测量62例（524扫描）。其中19名患者（172次扫描）还进行了射野图像。计算CBCT和EPID的平均值、系统设置误差（1）和随机设置误差（sigma）。比较了CBCT与EPID的差异以及CBCT的旋转摆位误差。结果：CBCT在颅-尾和前后方向上的摆位误差显著大于EPID的摆位误差（p <0.05），CBCT的摆位误差大于EPID的摆位误差（p < 0.05）。校正后CBCT测量的平均总体设置误差为0.2 mm（Sigma. 1.6 mm，σ = 2.9 mm），头-尾侧-0.8 mm（σ = 1.7 mm，或= 4.0 mm），以及0.0 mm（σ = 2.9 mm）。1.5 mm，σ = 2.0 mm）。使用我们的校正协议，只有2例患者的平均设置误差大于5毫米，没有这个校正协议的51%的患者将有一个设置误差大于5毫米。结论：使用CBCT扫描提供了更准确的信息设置肺癌患者比门静脉成像。(C)2007年爱思唯尔公司
Purpose: Kilovoltage cone-beam computed tomography (CBCT) has been developed to provide accurate soft-tissue and bony setup information. We evaluated clinical CBCT setup data and compared CBCT measurements with electronic portal imaging device (EPID) images for lung cancer patients.Methods and Materials: The setup error for CBCT scans at the treatment unit relative to the planning CT was measured for 62 patients (524 scans). For 19 of these patients (172 scans) portal images were also made. The mean, systematic setup error (1), and random setup error (sigma) were calculated for the CBCT and the EPID. The differences between CBCT and EPID and the rotational setup error derived from the CBCT were also evaluated. An offline shrinking action level correction protocol, based on the CBCT measurements, was used to reduce systematic setup errors and the impact of this protocol was evaluated.Results: The CBCT setup errors were significantly larger than the EPID setup errors for the cranial- caudal and anterior-posterior directions (p < 0.05). The mean overall setup errors after correction measured with the CBCT were 0.2 mm (Sigma. 1.6 mm, sigma = 2.9 mm) in the left-right, -0.8 mm (Sigma = 1.7 mm, or = 4.0 mm) in cranial-caudal and 0.0 mm (Sigma. 1.5 mm, sigma = 2.0 mm) in the anterior-posterior direction. Using our correction protocol only 2 patients had mean setup errors larger than 5 mm, without this correction protocol 51% of the patients would have had a setup error larger than 5 mm.Conclusion: Use of CBCT scans provided more accurate information concerning the setup of lung cancer patients than did portal imaging. (C) 2007 Elsevier Inc.