Computed tomography semi-automated lung volume quantification in SARS-CoV-2-related pneumonia.
Computed tomography semi-automated lung volume quantification in SARS-CoV-2-related pneumonia.
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DOI：
10.1007/s00330-020-07271-0
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发表时间：
2021-05
影响因子：
5.9
通讯作者：
Sironi S
中科院分区：
文献类型：
--
作者：
Ippolito D;Ragusi M;Gandola D;Maino C;Pecorelli A;Terrani S;Peroni M;Giandola T;Porta M;Talei Franzesi C;Sironi S
评估胸部计算机断层扫描 (CT) 的半自动分割和通气肺定量，以评估受 SARS-CoV-2 影响的患者的肺部受累程度。将结果与临床和功能参数及结果进行比较。所有图像均通过专用工作站进行定量分析，使用半自动肺分割软件计算通气肺容量 (VLV)、毛玻璃混浊 (GGO) 体积 (GGO-V) 和实变体积 (CONS-V)（作为绝对体积和占肺总体积 (TLV) 的百分比）。计算 CONS-V、GGO-V 和 VLV 之间的比率（分别为 CONS-V/VLV 和 GGO-V/VLV）、TLV（分别为 CONS-V/TLV、GGO-V/TLV 和 GGO-V + CONS-V/TLV）以及 VLV 和 TLV 之间的比率 (VLV/TLV)。共有 108 名患者入组。 GGO-V/TLV 与 WBC (r = 0.369)、中性粒细胞 (r = 0.446)、血小板 (r = 0.182)、CRP (r = 0.190)、PaCO2 (r = 0.176)、HCO3− 显着相关(r = 0.284) 和 PaO2/FiO2 (P/F) 值 (r = − 0.344)。 CONS-V/TLV 与 WBC (r = 0.294)、中性粒细胞 (r = 0.300)、淋巴细胞 (r = −0.225)、CRP (r = 0.306)、PaCO2 (r = 0.227)、pH 显着相关(r = 0.162)、HCO3− (r = 0.394) 和 P/F (r = − 0.419) 值。 CONS-V、GGO-V、GGO-V/TLV、CONS-V/TLV、GGO-V/VLV、CONS-V/VLV、GGO-V + CONS-V/TLV、VLV/TLV、CT 评分和 ET 有创通气之间存在统计学显着差异（所有 p<<0.05）。使用定量半自动算法进行肺部 CT 阐述，有效地将 SARS-CoV-2 相关肺炎的严重程度与实验室参数和有创通气的需求联系起来。 • 病理肺体积（以 GGO-V 和 CONS-V 表示）可被认为是治疗 SARS-CoV-2 相关肺炎的有用工具。 • 所有肺体积（以TLV 和VLV 的比率表示）与实验室数据相关，特别是C 反应蛋白和白细胞计数。 • 所有肺容量都与患者的结果相关，特别是有创通气。
To evaluate a semi-automated segmentation and ventilated lung quantification on chest computed tomography (CT) to assess lung involvement in patients affected by SARS-CoV-2. Results were compared with clinical and functional parameters and outcomes. All images underwent quantitative analyses with a dedicated workstation using a semi-automatic lung segmentation software to compute ventilated lung volume (VLV), Ground-glass opacity (GGO) volume (GGO-V), and consolidation volume (CONS-V) as absolute volume and as a percentage of total lung volume (TLV). The ratio between CONS-V, GGO-V, and VLV (CONS-V/VLV and GGO-V/VLV, respectively), TLV (CONS-V/TLV, GGO-V/TLV, and GGO-V + CONS-V/TLV respectively), and the ratio between VLV and TLV (VLV/TLV) were calculated. A total of 108 patients were enrolled. GGO-V/TLV significantly correlated with WBC (r = 0.369), neutrophils (r = 0.446), platelets (r = 0.182), CRP (r = 0.190), PaCO2 (r = 0.176), HCO3− (r = 0.284), and PaO2/FiO2 (P/F) values (r = − 0.344). CONS-V/TLV significantly correlated with WBC (r = 0.294), neutrophils (r = 0.300), lymphocytes (r = −0.225), CRP (r = 0.306), PaCO2 (r = 0.227), pH (r = 0.162), HCO3− (r = 0.394), and P/F (r = − 0.419) values. Statistically significant differences between CONS-V, GGO-V, GGO-V/TLV, CONS-V/TLV, GGO-V/VLV, CONS-V/VLV, GGO-V + CONS-V/TLV, VLV/TLV, CT score, and invasive ventilation by ET were found (all p < 0.05). The use of quantitative semi-automated algorithm for lung CT elaboration effectively correlates the severity of SARS-CoV-2-related pneumonia with laboratory parameters and the need for invasive ventilation. • Pathological lung volumes, expressed both as GGO-V and as CONS-V, can be considered a useful tool in SARS-CoV-2-related pneumonia. • All lung volumes, expressed themselves and as ratio with TLV and VLV, correlate with laboratory data, in particular C-reactive protein and white blood cell count. • All lung volumes correlate with patient’s outcome, in particular concerning invasive ventilation.
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影响因子：
6.7
作者：
Zach JA;Newell JD Jr;Schroeder J;Murphy JR;Curran-Everett D;Hoffman EA;Westgate PM;Han MK;Silverman EK;Crapo JD;Lynch DA;COPDGene Investigators
通讯作者：
COPDGene Investigators
影响因子：
5.9
作者：
Lanza, Ezio;Muglia, Riccardo;Balzarini, Luca
通讯作者：
Balzarini, Luca
影响因子：
3.3
作者：
Fischer, Andreas M.;Varga-Szemes, Akos;Schoepf, U. Joseph
通讯作者：
Schoepf, U. Joseph
影响因子：
8.9
作者：
Belfiore, Maria Paola;Urraro, Fabrizio;Reginelli, Alfonso
通讯作者：
Reginelli, Alfonso
影响因子：
1.6
作者：
Bae K;Jeon KN;Lee SJ;Kim HC;Ha JY;Park SE;Baek HJ;Choi BH;Cho SB;Moon JI
通讯作者：
Moon JI