One-pot quinazolin-4-yl-thiourea synthesis via N-(2-cyanophenyl)benzimidoyl isothiocyanate
One-pot quinazolin-4-yl-thiourea synthesis via N-(2-cyanophenyl)benzimidoyl isothiocyanate
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DOI：
10.3390/60700588
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发表时间：
2001-07-01
期刊：
影响因子：
4.6
通讯作者：
Pazdera, P
中科院分区：
文献类型：
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作者：
Fathalla, W;Cajan, M;Pazdera, P
通过1-取代-3-[（2-氰基苯亚氨基）苯甲基]硫脲（3）的分子内环加成反应，合成了1-取代-3-（2-苯基喹唑啉-4-基）硫脲（7）。这些化合物依次通过N-（2-氰基苯基）苯亚氨基异硫氰酸酯（2）与伯胺反应制备。产物7的结构经FTIR、H-1-NMR、C-13-NMR、质谱和X-射线衍射确证。
1-substituted-3-(2-phenylquinazolin-4-yl) thioureas (7) were produced by an intramolecular cycloaddition reaction of 1-substitued-3-[(2-cyanophenylimino)phenylmethyl] thioureas (3). These compounds in turn were prepared by the reaction of N-(2-cyanophenyl)benzimidoyl isothiocyanate (2) with primary amines. The structures of products 7 were confirmed by FTIR, H-1-NMR, C-13-NMR, mass spectroscopy and X-ray crystallography.