The partial mu opiate agonist buprenorphine protects a sub-population of thalamic reticular neurons following cardiac arrest in rats.
The partial mu opiate agonist buprenorphine protects a sub-population of thalamic reticular neurons following cardiac arrest in rats.
复制标题
部分μ阿片受体激动剂丁丙诺啡可保护大鼠心脏骤停后丘脑网状神经元的亚群。
DOI：
10.1016/0304-3940(94)11232-8
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发表时间：
1995
影响因子：
2.5
通讯作者：
Ross,DT
中科院分区：
文献类型：
--
作者：
Jones,MK;Ross,DT
在心脏骤停10分钟后复苏的大鼠中，从丘脑网状核（RT）的中间区域发生广泛的神经元损失。复苏后45分钟给予部分μ阿片受体激动剂丁丙诺啡，沿中间RT的内侧和外侧边缘（μ受体已定位的区域）的备用神经元沿着少量但显著增加。μ受体激动剂的全身给药可能会增加内源性阿片机制，有助于RT神经元亚群的相对缺血抵抗力。
Extensive loss of neurons occurs from the middle region of the thalamic reticular nucleus (RT) in rats resuscitated after 10 min of cardiac arrest. Administration of the partial μ opiate agonist buprenorphine 45 min after resuscitation produces a small but significant increase in spared neurons along the medial and lateral margins of the middle RT, regions where μ receptors have been localized. Systemic administration of μ agonists may augment endogenous opiate mechanisms that contribute to the relative ischemic resistance of subpopulations of RT neurons.