The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease.
The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease.
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DOI：
10.1001/archneur.58.9.1425
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发表时间：
2001-09
影响因子：
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通讯作者：
Danielle L. Sukonick;B. Pollock;R. Sweet;B. Mulsant;J. Rosen;W. Klunk;K. Kastango;S. DeKosky;R. Ferrell
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文献类型：
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作者：
Danielle L. Sukonick;B. Pollock;R. Sweet;B. Mulsant;J. Rosen;W. Klunk;K. Kastango;S. DeKosky;R. Ferrell
阿尔茨海默病（AD）的攻击行为与5-羟色胺神经传递功能障碍有关。5-羟色胺转运蛋白启动子区（5-HTTPR）的双等位基因多态性的长变体（*L）的纯合性与转运蛋白表达增加和对5-羟色胺再摄取抑制剂治疗的反应速度增加相关。目的探讨 *L/*L基因型和 *L等位基因是否与AD患者侵袭性症状风险增加相关。设计病例对照研究。设置大学医院老年精神病学住院项目和阿尔茨海默病研究中心。58例有攻击行为史的AD患者和79例无攻击行为的AD患者，认知功能障碍的严重程度相当。主要观察指标5-HTTPR基因型及等位基因频率。结果：*L/*L基因型与AD患者的攻击行为显著相关（比值比，2.8; 95%可信区间，1.2-6.5）。*L等位基因频率也得到了类似的结果。结论5-HTTPR*L等位基因和 *L/*L基因型可能是AD患者攻击行为的易感基因。
BACKGROUND Aggressive behavior in Alzheimer disease (AD) has been linked to dysfunction of serotonin neurotransmission. Homozygosity for the long variant (*L) of an identified biallelic polymorphism of the serotonin transporter promoter region (5-HTTPR) is associated with increased expression of the transporter protein and increased speed of response to serotonin reuptake inhibitor treatment. OBJECTIVE To determine whether the *L/*L genotype and the *L allele are associated with an increased risk of aggressive symptoms in patients with AD. DESIGN Case-control study. SETTING University hospital geriatric psychiatry inpatient program and Alzheimer disease research center. SUBJECTS Fifty-eight patients with AD with a history of aggressive behavior and 79 never-aggressive patients with AD with comparable severity of cognitive impairment. MAIN OUTCOME MEASURES The 5-HTTPR genotype and allele frequency. RESULTS The *L/*L genotype was significantly associated with aggression in patients with AD (odds ratio, 2.8; 95% confidence interval, 1.2-6.5). Similar results were obtained for *L allele frequency. CONCLUSION The 5-HTTPR*L allele and *L/*L genotype may predispose patients with AD to develop aggressive behavior.