Preferential brain locations of low-grade gliomas
Preferential brain locations of low-grade gliomas
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DOI：
10.1002/cncr.20297
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发表时间：
2004-06-12
期刊：
影响因子：
6.2
通讯作者：
Capelle, L
中科院分区：
文献类型：
--
作者：
Duffau, H;Capelle, L
背景本研究的目的是登记在一系列连续的低级别胶质瘤（LGGs）的大脑位置，并将这些定位与在同一时期收集的新生胶质母细胞瘤（GBM）的位置进行比较，以分析LGGs是否位于优先区域，并回顾这种现象的病理生理学假设。132例LGG和102例GBM患者在1996年至2003年期间连续随访，作者进行了审查，无论他们的治疗。使用解剖学，三维磁共振成像，每个肿瘤的位置进行了准确的分析，根据分类系统的基础上，邻近的功能区先前报告的作者。109例LGG（82.6%）位于功能区，55例GBM（53.9%）位于功能区（P < 0.001）。更具体地说，36个LGG（27.3%）与11个GBM（10.8%）相比，位于补充运动区（SMA）（P < 0.001）; 33个LGG（25%）与11个GBM（10.8%）相比，位于延髓（P < 0.001）。目前的研究结果表明，LGGs优先位于“次要”功能区（紧邻所谓的主要功能区），特别是在SMA和岛叶。这种优先定位可以解释为发育，cytomyeloarchitectonic，神经化学，代谢和功能的原因。更好地了解潜在的优先LGGs位置的病理生理机制，可以提高这些肿瘤的起源和自然史的理解，随后，他们的管理。(C)2004年美国癌症协会。
BACKGROUND. The objectives of this study were to register the brain locations in a consecutive series of low-grade gliomas (LGGs) and compare these localizations with the locations of de novo glioblastomas (GBMs) that were collected during the same period in an effort to analyze whether LGGs are situated in preferential areas and to review the pathophysiologic hypothesis of such a phenomenon.METHODS. One hundred thirty-two patients with LGG and 102 patients with GBM who were followed consecutively between 1996 and 2003 by the authors were reviewed, whatever their treatment. Using anatomic, three-dimensional magnetic resonance imaging, the location of each tumor was analyzed accurately according to a classification system based on the proximity of eloquent areas previously reported by the authors.RESULTS. One hundred nine LGGs (82.6%), compared with 55 GBMs (53.9%), were situated within functional regions (P < 0.001). More specifically, 36 LGGs (27.3%), compared with 11 GBMs (10.8%), were localized in the region of the supplementary motor area (SMA) (P < 0.001); and 33 LGGs (25%), compared with 11 GBMs (10.8%), were located within the insula (P < 0.001).CONCLUSIONS. The current findings suggest that LGGs are located preferentially in "secondary" functional areas (immediately near the so-called primary eloquent regions), especially within the SMA and the insular lobe. This preferential localization may be explained by developmental, cytomyeloarchitectonic, neurochemical, metabolic, and functional reasons. A better knowledge of the pathophysiologic mechanisms underlying preferential LGGs locations may improve understanding of the genesis and natural history of these tumors and, subsequently, their management. (C) 2004 American Cancer Society.