Atherosclerotic Plaque Composition and Classification Identified by Coronary Computed Tomography Assessment of Computed Tomography-Generated Plaque Maps Compared With Virtual Histology Intravascular Ultrasound and Histology
Atherosclerotic Plaque Composition and Classification Identified by Coronary Computed Tomography Assessment of Computed Tomography-Generated Plaque Maps Compared With Virtual Histology Intravascular Ultrasound and Histology
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DOI：
10.1161/circimaging.112.000250
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发表时间：
2013-09-01
影响因子：
7.5
通讯作者：
Bennett, Martin R.
中科院分区：
文献类型：
--
作者：
Obaid, Daniel R.;Calvert, Patrick A.;Bennett, Martin R.
背景计算机断层扫描（CT）常规用于冠状动脉造影，也可以识别斑块的高风险特征。然而，CT的能力来区分个别斑块成分和分类斑块根据公认的组织学definitions.Methods和结果，我们首先确定了CT衰减范围为个别斑块成分结合在体内CT coregistered与虚拟组织学血管内超声（VH-IVUS）在108斑块57例。与造影剂衰减的比较产生的斑块/造影剂衰减比对于每个组件显著不同。在47名患者的单独验证队列中，这些斑块图与VH-IVUS确定的斑块成分体积显著相关（坏死核心：r=0.41，P=0.002;纤维斑块：r=0.54，P
Background Computed tomography (CT) is used routinely for coronary angiography, and higher-risk features of plaques can also be identified. However, the ability of CT to discriminate individual plaque components and classify plaques according to accepted histological definitions is unknown.Methods and Results We first determined CT attenuation ranges for individual plaque components using combined in vivo CT coregistered with virtual histology intravascular ultrasound (VH-IVUS) in 108 plaques from 57 patients. Comparison with contrast attenuation created plaque/contrast attenuation ratios that were significantly different for each component. In a separate validation cohort of 47 patients, these Plaque Maps correlated significantly with VH-IVUS-determined plaque component volumes (necrotic core: r=0.41, P=0.002; fibrous plaque: r=0.54, P