The Necessity of Rostrolateral Prefrontal Cortex for Higher-Level Sequential Behavior.
The Necessity of Rostrolateral Prefrontal Cortex for Higher-Level Sequential Behavior.
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DOI：
10.1016/j.neuron.2015.08.026
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发表时间：
2015-09-23
期刊：
影响因子：
16.2
通讯作者：
Badre D
中科院分区：
文献类型：
--
作者：
Desrochers TM;Chatham CH;Badre D
额叶新皮层被认为支持我们最高的智力能力，包括我们计划和执行一系列任务以实现预期目标的能力。在日常生活中，这样的任务序列是抽象的，因为它们不需要一致的运动序列，并且通常是“即时”组装的。然而，非常少的是已知的必要性，这种控制的前沿子区域。参与者在fMRI扫描过程中重复完成一系列简单的任务。头外侧前额叶皮层（RLPFC）激活斜坡序列的位置，并重置在每个新的序列开始。为了建立RLPFC在这项任务中的必要性和功能，参与者进行了顺序任务，同时接受经颅磁刺激（TMS）的RLPFC与两个前额叶控制区。在两个独立的实验中，只有RLPFC刺激随着每个序列的进展而越来越扰乱任务表现。这些数据建立RLPFC作为必要的不确定性决议在序列级控制。
Frontal neocortex is thought to support our highest intellectual abilities, including our ability to plan and enact a sequence of tasks toward a desired goal. In everyday life, such task sequences are abstract in that they do not require consistent movement sequences and are often assembled “on the fly”. Yet, remarkably little is known about the necessity of frontal sub-regions for such control. Participants repeatedly completed sequences of simple tasks during fMRI scanning. Rostrolateral prefrontal cortex (RLPFC) activation ramped over sequence position, and reset at the initiation of each new sequence. To establish the necessity and function of RLPFC in this task, participants performed the sequential task while undergoing transcranial magnetic stimulation (TMS) of the RLPFC versus two prefrontal control regions. Across two independent experiments, only RLPFC stimulation increasingly disrupted task performance as each sequence progressed. These data establish RLPFC as necessary for uncertainty resolution during sequence-level control.