New Data-based Cutoffs for Maximal Exercise Criteria across the Lifespan
New Data-based Cutoffs for Maximal Exercise Criteria across the Lifespan
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DOI：
10.1249/mss.0000000000002344
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发表时间：
2020-09-01
期刊：
影响因子：
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通讯作者：
Knaier, Raphael
中科院分区：
文献类型：
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作者：
Wagner, Jonathan;Niemeyer, Max;Knaier, Raphael
目的：确定无运动限制性慢性疾病的一般人群的二次耗竭标准的年龄依赖性截止值;描述心肺运动试验（CPET）期间达到常用耗竭标准的参与者百分比;并分析他们在相应标准下的摄氧量，以量化给定标准对相应摄氧量（V/dotO（2））值的影响。方法：对20至91岁的参与者进行了COmPLETE健康研究的数据分析。所有人都接受了CPET，以最大的自愿行使使用自行车测力计。为了确定新的衰竭标准，基于最大呼吸交换率（RERmax）和年龄预测的最大HR（APMHR），使用95%的置信水平和90%的覆盖率计算确认（V）超过dotO（2）平台状态的试验的单侧下限容许区间。结果：共有274名男性和252名女性参与了这项研究。参与者几乎均匀分布在20岁至>80岁的年龄段。A（V）超过dotO（2）平台的占32%。表现出（V）超过dotO（2）平台期的参与者和未表现出（V）超过dotO（2）平台期的参与者之间的次要耗竭标准只有微小差异。根据20至39岁年龄组的容许区间，新的耗竭标准为：RERmax >= 1.13，APMHR（210）-年龄>= 96%，APMHR（208）x 0.7年龄>= 93%;对于40至59岁年龄组：RERmax >= 1.10，APMHR（210）-年龄>= 99%，APMHR（208）x 0.7年龄>= 92%; 60 - 69岁年龄组：RERmax >= 1.06，APMHR（210）-年龄>= 99%，APMHR（208）x 0.7年龄>= 89%。结论：次要标准的建议截止值降低了低估（V）超过dotO（2 max）的风险。较低的值将增加假阳性结果，假设参与者已经筋疲力尽，但事实上他们并没有。
Purpose: To determine age-dependent cutoff values for secondary exhaustion criteria for a general population free of exercise limiting chronic conditions; to describe the percentage of participants reaching commonly used exhaustion criteria during a cardiopulmonary exercise test (CPET); and to analyze their oxygen uptake at the respective criteria to quantify the impact of a given criterion on the respective oxygen uptake ((V)over dotO(2)) values. Methods: Data from the COmPLETE-Health Study were analyzed involving participants from 20 to 91 yr of age. All underwent a CPET to maximal voluntary exertion using a cycle ergometer. To determine new exhaustion criteria, based on maximal respiratory exchange ratio (RERmax) and age-predicted maximal HR (APMHR), one-sided lower tolerance intervals for the tests confirming (V)over dotO(2) plateau status were calculated using a confidence level of 95% and a coverage of 90%. Results: A total of 274 men and 252 women participated in the study. Participants were nearly equally distributed across age decades from 20 to >80 yr. A (V)over dotO(2) plateau was present in 32%. There were only minor differences in secondary exhaustion criteria between participants exhibiting a (V)over dotO(2) plateau and participants not showing a (V)over dotO(2) plateau. New exhaustion criteria according to the tolerance intervals for the age group of 20 to 39 yr were: RERmax >= 1.13, APMHR(210)- age >= 96%, and APMHR(208)x 0.7 age >= 93%; for the age group of 40 to 59 yr: RERmax >= 1.10, APMHR(210)- age >= 99%, and APMHR(208) x 0.7 age >= 92%; and, for the age group of 60 to 69 yr: RERmax >= 1.06, APMHR(210)- age >= 99%, and APMHR(208) x 0.7 age >= 89%. Conclusions: The proposed cutoff values for secondary criteria reduce the risk of underestimating (V)over dotO(2max). Lower values would increase false-positive results, assuming participants are exhausted although, in fact, they are not.