Two New Cytotoxic Quinone Type Compounds from the Halotolerant Fungus Aspergillus variecolor
Two New Cytotoxic Quinone Type Compounds from the Halotolerant Fungus Aspergillus variecolor
复制标题
DOI：
10.1038/ja.2007.77
复制
发表时间：
2007-10
期刊：
影响因子：
--
通讯作者：
Wen‐liang Wang;T. Zhu;Hong-Wen Tao;Zhenyu Lu;Yuchun Fang;Q. Gu;Weiming Zhu
中科院分区：
文献类型：
--
作者：
Wen‐liang Wang;T. Zhu;Hong-Wen Tao;Zhenyu Lu;Yuchun Fang;Q. Gu;Weiming Zhu
从耐盐真菌变色曲霉B-17产生的代谢产物中分离得到两个新的苯二酚类化合物，变色苯醌A(1)和B(2)，以及11个已知的相关化合物3∼13。用波谱方法确定了化合物1和2的结构。1对A-549细胞具有选择性杀伤作用，IC50值为3.0μM；2对HL60和P388细胞具有选择性杀伤作用，IC50分别为1.3和3.7μM。
Two new quinone type compounds, variecolorquinones A (1) and B (2) together with eleven known related compounds 3∼ 13 have been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structures of 1 and 2 were determined by spectroscopic methods. 1 exhibited selective cytotoxicity against A-549 cells with the IC 50 values of 3.0 μM. 2 showed cytotoxicity against HL60 and P388 cells with the IC 50 values of 1.3 and 3.7 μM, respectively.