Enantioselective Synthesis and Epimerization Behavior of a Chiral S-Shaped [11]Helicene-Like Molecule Having Collision between Terminal Benzene Rings
Enantioselective Synthesis and Epimerization Behavior of a Chiral S-Shaped [11]Helicene-Like Molecule Having Collision between Terminal Benzene Rings
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DOI：
10.1002/ejoc.201801694
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发表时间：
2019-02-14
影响因子：
2.8
通讯作者：
Tanaka, Ken
中科院分区：
文献类型：
--
作者：
Kimura, Yuki;Shibata, Yu;Tanaka, Ken
通过铑（I）/（R）-二氟膦配合物介导的2-萘酚连接的己炔的对映选择性分子内双[2+2+2]环加成反应，可以合成具有高ee值沿着内消旋构型的手性S形[11]螺烯类分子，尽管该手性螺烯的末端苯环之间存在碰撞.还公开了手性和内消旋[11]螺烯类分子的差向异构化行为。
It has been established that a chiral S-shaped [11]helicene-like molecule can be synthesized with high ee value along with a meso form by the rhodium(I)/(R)-difluorphos complex-mediated enantioselective intramolecular double [2+2+2] cycloaddition of a 2-naphthol-linked hexayne, even though this chiral helicene has the collision between the terminal benzene rings. Epimerization behavior of the chiral and meso [11]helicene-like molecules have also been disclosed.