T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase.
T cell regulatory plasmacytoid dendritic cells expressing indoleamine 2,3 dioxygenase.
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DOI：
10.1007/978-3-540-71029-5_8
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发表时间：
2009
影响因子：
--
通讯作者：
Mellor AL
中科院分区：
文献类型：
--
作者：
Kahler DJ;Mellor AL
Mature dendritic cells (DCs) are potent stimulators of T cells that recognize antigens presented by the DCs. In this chapter we describe mature DCs that suppress T cell responses to antigens they present due to expression of the intracellular enzyme indoleamine 2,3 dioxygenase (IDO). IDO-competent DCs are a subset of plasmacytoid DCs that can be induced to express IDO under certain inflammatory conditions in humans and mice. Though rare, IDO-expressing DCs acquire potent T cell suppressor activity that may predominate over the T cell stimulatory functions of all other antigen-presenting cells in physiologic environments due in part, to cooperation with regulatory T cells. Thus, IDO-expressing DCs are critical regulators of adaptive immunity that contribute to a wide range of inflammatory disease processes. As such, manipulating IDO expression in DCs using IDO inhibitors or IDO inducers offers considerable opportunities to improve immunotherapies in a range of clinically-significant disease syndromes.
