Development and validation of new diagnostic criteria for atopic dermatitis in children of China
Development and validation of new diagnostic criteria for atopic dermatitis in children of China
复制标题
中国儿童特应性皮炎新诊断标准的制定和验证
DOI：
10.1111/jdv.15979
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发表时间：
2020-03-01
影响因子：
9.2
通讯作者：
Yao, Z.
中科院分区：
文献类型：
--
作者：
Cheng, R.;Zhang, H.;Yao, Z.
背景在以往的流行病学研究中，1-7岁儿童特应性皮炎（AD）的患病率按临床诊断为12.94%，而按英国、英国、英国和美国的诊断率分别为4.76%和3.51%，和Hanifin和拉伊卡诊断标准。我们的目的是提出新的诊断标准，为儿童和评估其效率在不同population.MethodsWe筛选特应性功能和分析其相关性与AD使用数据从以前的研究。提出了一套新的儿童诊断标准，并在1031名门诊儿童和538名出生队列调查儿童中进行了验证。临床诊断和特应性特征评估由专门从事AD的皮肤科医生面对面进行。三个标准进行了比较的诊断效率使用的临床诊断为reference.ResultsThe新的诊断标准为儿童的基础上（一）瘙痒症;（二）“典型的形态和分布”或“非典型的形态和分布与干燥症”;和（iii）慢性或慢性复发过程。与经典诊断标准相比，新诊断标准在流行病学调查和临床环境中的敏感性明显提高，尤其在轻中度AD中更为明显。在出生队列中，新的标准表现出类似的灵敏度和specificity.ConclusionThe新的标准为儿童AD的诊断在流行病学调查和临床设置，特别是轻度和中度AD的敏感性更高。在有完整病史的出生队列中，三个标准显示出相似的敏感性和特异性。比伯。J Eur Acad Dermatol Venereol 2020; 34：438-439. .
BackgroundIn previous epidemiological study, the prevalence of atopic dermatitis (AD) was 12.94% among children aged 1-7 years by clinical diagnosis, whereas that was 4.76% and 3.51% using U.K., and Hanifin and Rajka diagnostic criteria.ObjectiveWe aimed to propose new diagnostic criteria for children and evaluate its efficiency in different populations.MethodsWe screened atopic features and analysed their correlation with AD using data from a previous study. A new set of diagnostic criteria for children in China was proposed and validated in 1031 children in outpatient clinics and 538 children in a birth cohort survey. Clinical diagnosis and atopic feature evaluation were performed face to face by dermatologists specialized in AD. Three criteria were compared for diagnostic efficiency using the clinical diagnosis as the reference.ResultsThe new diagnostic criteria for children were based on (i) pruritus; (ii) 'typical morphology and distribution' or 'atypical morphology and distribution with xerosis'; and (iii) a chronic or chronically relapsing course. Compared to classical diagnostic criteria, the sensitivity of the new diagnostic criteria was significantly higher in the epidemiological survey and the clinical setting, especially obvious among mild and moderate AD. In the birth cohort, the new criteria showed similar sensitivity and specificity.ConclusionThe new criteria for children yielded higher sensitivity for the diagnosis of AD in the epidemiological survey and clinical setting, particularly for mild and moderate AD. Among the birth cohort with a complete medical history, three criteria showed similar sensitivity and specificity.Linked Commentary: T. Bieber. J Eur Acad Dermatol Venereol 2020; 34: 438-439. .