Modulation of Presaccadic Activity in the Frontal Eye Field by the Superior Colliculus
Modulation of Presaccadic Activity in the Frontal Eye Field by the Superior Colliculus
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DOI：
10.1152/jn.00053.2009
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发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Wurtz, Robert H.
中科院分区：
文献类型：
--
作者：
Berman, Rebecca A.;Joiner, Wilsaan M.;Wurtz, Robert H.
Berman RA、Joiner WM、Cavanaugh J、Wurtz RH。上丘对额眼视野中眼跳前活动的调节。 J Neurophysiol 101: 2934-2942, 2009。首次发表于 2009 年 3 月 25 日； doi：10.1152/jn.00053.2009。在每次眼球扫视运动到视觉场景中的目标之前，都会产生一系列神经元信号。在大脑皮层中，这种神经元处理在额叶视野 (FEF) 中达到顶峰，其中神经元在眼跳之前会爆发活动。这种眼跳前活动通常被认为驱动上丘 (SC) 中间层的下游活动，该层接收 FEF 的直接投射。因此，FEF 活动被认为仅由早期皮质处理决定，不受 SC 活动的影响。然而，最近从 SC 到 FEF 的上升路径的证据提出了一种可能性，即 FEF 中的眼跳前活动也可能取决于 SC 的输入。在这里，我们通过在 SC 可逆失活过程中记录单个 FEF 神经元来测试这种可能性。我们的结果表明，FEF 中的眼跳前活动不需要 SC 输入：当 SC 失活时，我们从未观察到 FEF 眼跳前活动显着减少。出乎意料的是，在三分之一的实验中，SC 失活引起了 FEF 眼跳前活动的显着增加。相反，FEF 神经元的被动视觉反应几乎不受 SC 失活的影响。这些发现表明，FEF 中的眼跳前活动并非起源于 SC，但可能受到从 SC 上升的调节信号的影响。
Berman RA, Joiner WM, Cavanaugh J, Wurtz RH. Modulation of presaccadic activity in the frontal eye field by the superior colliculus. J Neurophysiol 101: 2934-2942, 2009. First published March 25, 2009; doi: 10.1152/jn.00053.2009. A cascade of neuronal signals precedes each saccadic eye movement to targets in the visual scene. In the cerebral cortex, this neuronal processing culminates in the frontal eye field (FEF), where neurons have bursts of activity before the saccade. This presaccadic activity is typically considered to drive downstream activity in the intermediate layers of the superior colliculus (SC), which receives direct projections from FEF. Consequently, the FEF activity is thought to be determined solely by earlier cortical processing and unaffected by activity in the SC. Recent evidence of an ascending path from the SC to FEF raises the possibility, however, that presaccadic activity in the FEF may also depend on input from the SC. Here we tested this possibility by recording from single FEF neurons during the reversible inactivation of SC. Our results indicate that presaccadic activity in the FEF does not require SC input: we never observed a significant reduction in FEF presaccadic activity when the SC was inactivated. Unexpectedly, in a third of experiments, SC inactivation elicited a significant increase in FEF presaccadic activity. The passive visual response of FEF neurons, in contrast, was virtually unaffected by inactivation of the SC. These findings show that presaccadic activity in the FEF does not originate in the SC but nevertheless may be influenced by modulatory signals ascending from the SC.