Lysosome-related organelles: unusual compartments become mainstream.

Lysosome-related organelles: unusual compartments become mainstream.
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DOI:
10.1016/j.ceb.2013.04.008
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发表时间:
2013-08
影响因子:
7.5
通讯作者:
Raposo, Graca
Raposo, Graca
中科院分区:
生物学2区
文献类型:
--
作者:
Marks, Michael S.;Heijnen, Harry F. G.;Raposo, Graca

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溶酶体相关细胞器(LROs)是一组细胞类型特异性的亚细胞区室,具有独特的组成、形态和结构,与核内体和溶酶体具有某些共同的特征,并在色素沉着、止血、肺可塑性和免疫等过程中发挥作用。近年来,对LRO功能受损的遗传性疾病的研究为LRO的生物合成和LRO内容物的分泌调节机制提供了新的见解。这些见解揭示了以前不受重视的专门的内体分选过程中的所有细胞类型,并扩大了我们的观点的可塑性的内体和分泌系统,以适应细胞类型的特定需求。
Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular compartments with unique composition, morphology and structure that share some features with endosomes and lysosomes and that function in varied processes such as pigmentation, hemostasis, lung plasticity and immunity. In recent years, studies of genetic diseases in which LRO functions are compromised have provided new insights into the mechanisms of LRO biogenesis and the regulated secretion of LRO contents. These insights have revealed previously unappreciated specialized endosomal sorting processes in all cell types, and are expanding our views of the plasticity of the endosomal and secretory systems in adapting to cell type-specific needs.
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