Lysosome-related organelles: unusual compartments become mainstream.
Lysosome-related organelles: unusual compartments become mainstream.
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DOI:
10.1016/j.ceb.2013.04.008
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发表时间:
2013-08
影响因子:
7.5
通讯作者:
Raposo, Graca
中科院分区:
文献类型:
--
作者:
Marks, Michael S.;Heijnen, Harry F. G.;Raposo, Graca
Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular compartments with unique composition, morphology and structure that share some features with endosomes and lysosomes and that function in varied processes such as pigmentation, hemostasis, lung plasticity and immunity. In recent years, studies of genetic diseases in which LRO functions are compromised have provided new insights into the mechanisms of LRO biogenesis and the regulated secretion of LRO contents. These insights have revealed previously unappreciated specialized endosomal sorting processes in all cell types, and are expanding our views of the plasticity of the endosomal and secretory systems in adapting to cell type-specific needs.
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DOI:
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发表时间:
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期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
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