The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates
The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates
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DOI：
10.1016/j.jaut.2007.02.014
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发表时间：
2007-03-01
影响因子：
12.8
通讯作者：
Villinger, F.
中科院分区：
文献类型：
--
作者：
Ansari, Aftab A.;Pereira, Lara E.;Villinger, F.
恒河猴感染SIV后血清中出现自身抗体。本研究旨在研究病毒载量、抗病毒化疗和疾病分期对此类自身抗体滴度的作用，以及成为此类自身免疫反应靶点的自身抗原谱。此外，还检查了调节性T细胞（Treks）的作用。这些研究的结果表明，与血浆病毒载量相对较高和自身抗原谱较窄的动物中的较低自身抗体滴度相比，在具有较低相对血浆病毒载量和作为此类应答靶点的较宽自身抗原谱的动物中观察到最高自身抗体滴度。短期抗病毒化疗没有影响。自身抗体的滴度虽然THBE的频率和绝对数量逐渐减少，但THBE水平与病毒载量和较低的自身抗体滴度呈负相关。这些差异的机制仍然未知，并表明免疫抑制，自身免疫反应，稳态增殖和成为这种自身免疫反应的目标的自身抗原谱的水平之间存在复杂的关系。(C)2007爱思唯尔有限公司保留所有权利。
Autoantibodies appear in the sera of rhesus macaques following SIV infection. The present study was conducted to examine the role of viral load, antiviral chemotherapy and stage of disease on the titers of such autoantibodies and the spectrum of autoantigens that become the target of such autoimmune responses. In addition, the role of regulatory T cells (Treks) was also examined. Results of these studies showed that the highest autoantibody titers were noted in animals with lower relative plasma viral loads with a wider spectrum of autoantigens that are the target of such responses as compared with lower autoantibody titers in animals with relatively higher plasma viral loads and a narrower spectrum of autoantigens. Short-term antiviral chemotherapy did not influence. the titers of autoantibodies. While there was a gradual decrease in the frequency and absolute number of Tregs, the levels of Tregs was inversely correlated with viral load and lower autoantibody titers. The mechanisms for these differences remain unknown and suggest complex relationships exist between levels of immunosuppression, autoimmune response, homeostatic proliferation and the spectrum of autoantigens that become the target of such autoimmune responses. (C) 2007 Elsevier Ltd. All rights reserved.