Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility
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DOI：
10.1038/ng1524
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发表时间：
2005-04-01
期刊：
影响因子：
30.8
通讯作者：
Paigen, B
中科院分区：
文献类型：
--
作者：
Wang, XS;Ria, M;Paigen, B
Ath 1是小鼠1号染色体上的一个数量性状位点，它使C57 BL/6小鼠对饮食诱导的动脉粥样硬化易感，而C3 H/He小鼠对饮食诱导的动脉粥样硬化有抗性。数量性状基因座区域包括11个已知基因，包括Tnfsf 4（也称为Ox 40 l或Cd 134 l），其编码OX 40配体。在这里，我们报告了Tnfsf 4靶向突变的小鼠有显著（P
Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 ( also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly ( P