FLAIR☆: A Combined MR Contrast Technique for Visualizing White Matter Lesions and Parenchymal Veins
FLAIR☆: A Combined MR Contrast Technique for Visualizing White Matter Lesions and Parenchymal Veins
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DOI：
10.1148/radiol.12120208
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发表时间：
2012-12-01
期刊：
影响因子：
19.7
通讯作者：
Reich, Daniel S.
中科院分区：
文献类型：
--
作者：
Sati, Pascal;George, Ilena C.;Reich, Daniel S.
目的：评价磁共振（MR）成像对比技术，称为FLAIR（星星），结合T2加权液体衰减反转恢复（FLAIR）对比度和T2（星星）加权对比度的优点，在一个单一的图像评估白色（WM）疾病，如多发性硬化症（MS）。材料和方法：这项前瞻性试点研究是符合健康保险责任法案和机构审查委员会批准。10例临床确诊的MS患者（8例男性，2例女性;平均年龄41岁）提供了知情同意书，并接受了3.0 T MR成像。将T2加权FLAIR序列的图像与造影剂注射期间进行的T2（星星）加权分段回波平面成像序列的图像组合，产生高各向同性分辨率（0.55 x 0.55 x 0.55 mm（3））FLAIR（星星）图像。对图像质量、病变清晰度和静脉清晰度进行定性评估。对比噪声比（CNR）计算比较正常出现的WM（NAWM）与脑脊液，病变，静脉。为了评估CNR之间的成像方式的差异，引导程序集群的主题，配对t tests.Results：高品质的FLAIR（星星）图像的大脑在3.0 T，产生明显的病变和静脉。FLAIR（星星）图像的病变与NAWM和NAWM与静脉CNR值显著高于T2加权FLAIR图像（P <.0001）。FLAIR（星星）图像上的发现包括位于整个大脑和周围的一些WM lesions.Conclusion低信号边缘病变intralesional静脉：高各向同性分辨率FLAIR（星星）图像在3.0 T获得高对比度WM病变和实质静脉，使其非常适合于调查WM异常和静脉之间的关系在临床设置。(C)RSNA，2012年
Purpose: To evaluate a magnetic resonance (MR) imaging contrast technique, called FLAIR(star), that combines the advantages of T2-weighted fluid-attenuated inversion recovery (FLAIR) contrast and T2(star)-weighted contrast on a single image for assessment of white matter (WM) diseases such as multiple sclerosis (MS).Materials and Methods: This prospective pilot study was HIPAA compliant and institutional review board approved. Ten patients with clinically definite MS (eight men, two women; mean age, 41 years) provided informed consent and underwent 3.0-T MR imaging. Images from a T2-weighted FLAIR sequence were combined with images from a T2(star)-weighted segmented echo-planar imaging sequence performed during contrast material injection, yielding high-isotropic-resolution (0.55 x 0.55 x 0.55 mm(3)) FLAIR(star) images. Qualitative assessment was performed for image quality, lesion conspicuity, and vein conspicuity. Contrast-to-noise ratio (CNR) was calculated to compare normal-appearing WM (NAWM) with cerebrospinal fluid, lesions, and veins. To evaluate the differences in CNR among imaging modalities, a bootstrap procedure clustered on subjects was used, together with paired t tests.Results: High-quality FLAIR(star) images of the brain were produced at 3.0 T, yielding conspicuous lesions and veins. Lesion-to-NAWM and NAWM-to-vein CNR values were significantly higher for FLAIR(star) images than for T2-weighted FLAIR images (P < .0001). Findings on FLAIR(star) images included intralesional veins for lesions located throughout the brain and a hypointense rim around some WM lesions.Conclusion: High-isotropic-resolution FLAIR(star) images obtained at 3.0 T yield high contrast for WM lesions and parenchymal veins, making it well suited to investigate the relationship between WM abnormalities and veins in a clinical setting. (C) RSNA, 2012