The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys
The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys
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DOI：
10.1007/s00383-006-1839-9
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发表时间：
2007-02-01
影响因子：
1.8
通讯作者：
Hogdall, C.
中科院分区：
文献类型：
--
作者：
Cortes, D.;Thorup, J.;Hogdall, C.
在双侧睾丸固定术中，双侧活检可用于确定生育能力。目前尚不清楚睾丸固定术时血清白蛋白B水平是否反映了双侧隐睾患儿的睾丸状态。本研究的目的是将双侧隐睾男孩的睾丸素B和FSH测量结果与睾丸活检参数相关联。纳入了25例双侧隐睾的男孩，双侧隐睾手术时的平均年龄为2.5年（9个月至5.5年），同时进行睾丸活检，并采集血液样本进行卵泡刺激素B和FSH检测。对100例输卵管横切面进行精原细胞和生殖母细胞计数，求出患者的S/T和平均S/T，并以最低正常值的百分比表示。测量抑制素B和FSH，并与年龄特异性值相关。40%（10/25）的患者平均S/T非常低（平均S/T <最低正常值的10%）。24%（6/25）的患者抑制素B降低，均伴有平均S/T降低，主要是平均S/T <最低正常值的10%（p < 0.05）。B与FSH呈负相关（p < 0.05）。在S/T < 10%正常值和FSH B降低的病例中，我们发现9%（2/22）的患者FSH升高，怀疑高促性腺激素性性腺功能减退症。5%（1/22）的患者发现FSH低，怀疑低促性腺激素性性腺功能减退症。低胆红素B预示着严重的不孕症。FSH和FSH结合素B低提示低促性腺激素性性腺功能减退症。在双侧隐睾的男孩中，B水平与FSH水平呈负相关。
At bilateral orchiopexy bilateral biopsies may be indicated to determine fertility potential. It is currently unknown if the serum inhibin B levels at time of orchiopexy reflect the testicular status of the bilaterally cryptorchid child. The aim of this study was to relate the results of inhibin B and FSH measurements with testicular biopsy parameters in bilateral cryptorchid boys. Included were 25 boys with bilateral cryptorchidism, median 2.5 years (9 months to 5.5 years) at surgery for bilateral cryptorchidism with simultaneous testicular biopsies, and blood sample for inhibin B and FSH. The number of spermatogonia and gonocytes was measured in 100 tubular transverse sections, the S/T and the mean-S/T of the patient was found, and expressed as percent of lowest normal value. Inhibin B and FSH were measured and related to age-specific values. Forty percent (10/25) of the patients had very low mean-S/T (mean-S/T < 10% of lowest normal-value). Inhibin B was decreased in 24% (6/25) of the patients, all with decreased mean-S/T, predominantly with a mean-S/T < 10% of lowest normal-value (p < 0.05). There was a negative correlation between inhibin B and FSH (p < 0.05). In cases of mean-S/T < 10% of lowest normal-value and decreased inhibin B, we found increased FSH in 9% (2/22) of the patients and hypergonadotropic hypogonadism was suspected. Low FSH was found in 5% (1/22) of the patients and hypogonadotropic hypogonadism was suspected. Low inhibin B predicts a serious condition in respect of infertility. Low FSH and inhibin B indicates examination for hypogonadotropic hypogonadism. In bilateral cryptorchid boys inhibin B levels correlated negatively to FSH.