Overexpression of FOXM1 Is a Potential Prognostic Marker in Male Breast Cancer
Overexpression of FOXM1 Is a Potential Prognostic Marker in Male Breast Cancer
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DOI：
10.1159/000458156
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发表时间：
2017-04-01
影响因子：
2.4
通讯作者：
Gamoudi, Amor
中科院分区：
文献类型：
--
作者：
Abdeljaoued, Syrine;Bettaieb, Ilhem;Gamoudi, Amor
背景资料：一些研究概述了女性和男性乳腺癌（MBC）之间的生物学差异，并得出结论认为MBC应被视为一种完全独立的疾病。FOXM 1是否对MBC患者的预后有任何指示仍然未知。我们试图检测FOXM 1在MBC中的表达水平，并确定FOXM 1表达与患者生存率之间的关系。患者和方法：FOXM 1表达在总共130个MBC标本进行了评估。结果：FOXM 1在37%的MBC样本中过表达。FOXM 1过表达与肿瘤大小（p = 0.045）、组织学分级（p = 0.048）、淋巴结转移（p = 0.012）、Ki-67增殖指数（p = 0.016）和分子亚型（p < 0.001）显著相关。多变量分析表明FOXM 1是MBC患者总生存期的独立预后因素（p < 0.001，风险比= 0.69（0.43-0.96））。结论：FOXM 1的过表达与预后不良的成熟标志物相关，因此FOXM 1可能代表MBC的潜在新预后标志物。(C)2017 S. Karger GmbH，弗赖堡
Background: Several studies have outlined biological differences between female and male breast cancer (MBC) and concluded that MBC should be considered as an entirely separate disease. Whether FOXM1 has any indication for prognosis in MBC patients remains unknown. We sought to examine the expression levels of FOXM1 in MBC and to identify the relationship between FOXM1 expression and patient survival. Patients and Methods: FOXM1 expression was evaluated in a total of 130 MBC specimens. Results: FOXM1 was overexpressed in 37% of the MBC samples. FOXM1 overexpression was significantly associated with tumor size (p = 0.045), histological grade (p = 0.048), lymph node metastasis (p = 0.012), Ki-67 proliferation index (p = 0.016), and molecular subtypes (p < 0.001). Multivariate analyses indicated that FOXM1 was an independent prognostic factor for overall survival in MBC patients (p < 0.001, hazard ratio = 0.69 (0.43-0.96)). Conclusions: Overexpression of FOXM1 was associated with well-established markers of poor prognosis; thus FOXM1 may represent a potential novel prognostic marker for MBC. (C) 2017 S. Karger GmbH, Freiburg