Comparison of histological structure and biocompatibility between human acellular dermal matrix (ADM) and porcine ADM
Comparison of histological structure and biocompatibility between human acellular dermal matrix (ADM) and porcine ADM
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DOI：
10.1016/j.burns.2008.05.007
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发表时间：
2009-02-01
期刊：
影响因子：
2.7
通讯作者：
Wei, Hong
中科院分区：
文献类型：
--
作者：
Ge, Liangpeng;Zheng, Shuquan;Wei, Hong
比较人ADM和猪ADM的组织学结构和生物相容性。光镜和电镜观察人ADM和猪ADM的支架结构、胶原排列和胶原结构非常相似，只是黑色和白色带略有不同。猪ADM的胶原1、胶原111、胶原IV、纤连蛋白、层粘连蛋白和波形蛋白的免疫组化染色阳性结果和SDS-PAGE结果表明人ADM和猪ADM的主要蛋白质具有很强的同源性，统计学分析表明两种ADM的生物相容性无显著性差异（P < 0.05）。基于这些结果，我们认为猪ADM与人ADM具有很强的相似性，并且有可能成为人ADM的替代品。(C)2008 Elsevier Ltd和ISBI。All rights reserved.
The present study was to compare the difference of histological structure and biocompatibility between human ADM and porcine ADM. The scaffold structure, collagen arrangement and collagen structure of human ADM and those of porcine ADM were very similar except for a slight difference in their black and white bands assessed by both light microscopy and electron microscopy. The positive immunohistochemical staining results of porcine ADM using human antibodies of collagen 1, collagen 111, collagen IV, fibronectin, laminin and vimentin and the result of SDS-PAGE implied a strong homology between the main proteins of human ADM and porcine ADM. In addition, statistical analysis indicated that there was no significant difference (P < 0.05) between the biocompatibility of the two ADMs. Based on these results, we conclude that porcine ADM bears a strong similarity to human ADM, and might be a substitute for human ADM in the future. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.