MEMBRANE VISCOELASTICITY
MEMBRANE VISCOELASTICITY
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DOI：
10.1016/s0006-3495(76)85658-5
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发表时间：
1976-01-01
影响因子：
3.4
通讯作者：
HOCHMUTH, RM
中科院分区：
文献类型：
--
作者：
EVANS, EA;HOCHMUTH, RM
在本文中，我们开发了一个理论的粘弹性行为的大膜变形和应用分析的小微管抽吸红细胞discocytes产生的投影松弛。我们表明，这种松弛是由膜粘度和细胞质和细胞外液流的松弛时间的影响可以忽略不计，可以忽略不计。从初步的数据，我们估计总膜的“粘度”时，膜材料的行为在弹性固体的方式。总膜粘度计算为10（-3）dyn-s/cm，其是比脂质膜组分的表面粘度（如通过“流动性”测量确定的）大约三个数量级的表面粘度。很明显，脂双层对整个质膜的流体动力学行为贡献很小，结构基质主导粘性耗散。然而，我们发现，膜中的粘性流动并不负责产生溶解所需的各向同性膜张力的时间依赖性，并且兰德，Katchalsky等人，对于“粘度”来说，大了六到八个数量级。
In this paper, we develop a theory for viscoelastic behavior of large membrane deformations and apply the analysis to the relaxation of projections produced by small micropipette aspiration of red cell discocytes. We show that this relaxation is dominated by the membrane viscosity and that the cytoplasmic and extracellular fluid flow have negligible influence on the relaxation time and can be neglected. From preliminary data, we estimate the total membrane "viscosity" when the membrane material behaves in an elastic solid manner. The total membrane viscosity is calculated to be 10(-3) dyn-s/cm, which is a surface viscosity that is about three orders of magnitude greater than the surface viscosity of lipid membrane components (as determined by "fluidity" measurements). It is apparent that the lipid bilayer contributes little to the fluid dynamic behavior of the whole plasma membrane and that a structural matrix dominates the viscous dissipation. However, we show that viscous flow in the membrane is not responsible for the temporal dependence of the isotropic membrane tension required to produce lysis and that the previous estimates of Rand, Katchalsky, et al., for "viscosity" are six to eight orders of magnitude too large.