Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task
Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task
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DOI：
10.1016/j.brainres.2011.04.044
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发表时间：
2011-06-23
期刊：
影响因子：
2.9
通讯作者：
Yomoda, Satoshi
中科院分区：
文献类型：
--
作者：
Hamazaki-Fujita, Nina;Hamazaki, Kei;Yomoda, Satoshi
多不饱和脂肪酸对人脑血氧合的影响尚未得到广泛的研究。在这项研究中，招募了年龄在20至49岁之间的健康参与者（14名男性，40名女性）。所有女性参与者都是在月经周期开始时参加试验的。在测量前额叶皮层（PFC）的脑血氧之前，在进行两种问卷调查之前，采集血样，情绪状态概况（POMS）和关于参与者觉醒水平的问卷。在Uchida-Kraepelin性能测试（UKP）之前和期间，连续监测PFC的血氧。组织氧合指数(含氧血红蛋白与含氧血红蛋白+脱氧血红蛋白之比；to ！近红外光谱法测量脑血液循环简化指数。以性别、年龄、吸烟、饮酒为混杂因素进行多元回归分析。二十碳五烯酸（Eicosapentaenoic acid， EPA）与TO！，与觉醒水平正相关，与消极情绪负相关（POMS）。在UKP测试中，EPA和二十二碳六烯酸与抑郁-沮丧（POMS）呈负相关，与觉醒水平和整体表现呈正相关。我们认为EPA可能会增加PFC中的氧合水平，从而改善各种心理参数和性能。(C) 2011 Elsevier B.V.版权所有
The effects of polyunsaturated fatty acids on human cerebral blood oxygenation have yet to be extensively investigated. In this study, healthy participants (14 men, 40 women) aged between 20 and 49 years were recruited. All female participants entered the trial at the start of their menstrual cycle. Blood was sampled before measuring cerebral blood oxygenation in the prefrontal cortex (PFC) and prior to administering two kinds of questionnaires, the Profile of Mood States (POMS) and a questionnaire regarding participants' arousal level. Blood oxygenation in the PFC was continuously monitored immediately before and during the Uchida-Kraepelin Performance (UKP) test as a mental arithmetic task. Changes in the tissue oxygenation index (the ratio of oxyhemoglobin to oxyhemoglobin + deoxyhemoglobin; TO!, a simplified index for cerebral blood circulation) were measured by near-infrared spectroscopy. Multiple regression analysis was performed with sex, age, smoking and drinking as confounding factors. Eicosapentaenoic acid (EPA) was positively associated with TO!, which was positively associated with arousal level and inversely associated with negative mood (POMS). EPA and docosahexaenoic acid were inversely associated with depression-dejection (POMS) and positively associated with arousal level and overall performance in the UKP test. We suggest that EPA might increase the oxygenation level in the PFC, in turn improving various psychological parameters and performance. (C) 2011 Elsevier B.V. All rights reserved.