Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders
Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders
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DOI：
10.1515/revneuro-2018-0021
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发表时间：
2019-04-01
影响因子：
4.1
通讯作者：
Nampoothiri, Madhavan
中科院分区：
文献类型：
--
作者：
Eapen, Prasanth M.;Rao, Chamallamudi Mallikarjuna;Nampoothiri, Madhavan
具有天然底物P物质的神经激肽1受体是神经激肽受体中被深入研究的受体之一。细胞内信号传导机制使用G蛋白偶联转导调节从恶心到阿尔茨海默病的各种生理过程。神经激肽1受体在神经炎症介导的神经回路改变中起重要作用。神经激肽1受体拮抗剂是选择性的，有效的，并在神经系统疾病的动物模型中表现出功效。不断发展的数据现在加强了脑P物质/神经激肽1受体轴介导的神经回路功能障碍的作用的观点。因此，神经激肽1受体参与的疾病机制的深入分析对于增强疾病模型是必要的，这鼓励制药业加强研究管道。本文综述了神经激肽1受体信号通路与脑先天免疫系统的关系。我们还揭示了神经激肽1受体参与神经系统疾病的机制和各种调节神经激肽1受体的方法，这可能会导致治疗作用。
The neurokinin 1 receptor with the natural substrate substance P is one of the intensely studied receptors among the neurokinin receptors. The intracellular signaling mechanism uses G protein-coupled transduction regulating various physiological processes from nausea to Alzheimer's disease. The neurokinin 1 receptor plays a significant role in neuroinflammation-mediated alterations in neural circuitry. Neurokinin 1 receptor antagonists are selective, potent and exhibited efficacy in animal models of nervous system disorders. Evolving data now strengthen the viewpoint of brain substance P/neurokinin 1 receptor axis-mediated action in neural circuit dysfunction. Thus, a deep-rooted analysis of disease mechanism in which the neurokinin 1 receptor is involved is necessary for augmenting disease models which encourage the pharmaceutical industry to intensify the research pipeline. This review is an attempt to outline the concept of neurokinin 1 receptor signaling interlinked to the brain innate immune system. We also uncover the mechanisms of the neurokinin 1 receptor involved in neurological disorder and various methods of modulating the neurokinin 1 receptor, which may result in therapeutic action.