The dynamic behavior of lipid droplets in the pre-metastatic niche.
The dynamic behavior of lipid droplets in the pre-metastatic niche.
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转移前微环境中脂滴的动态行为
DOI：
10.1038/s41419-020-03207-0
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发表时间：
2020-11-17
影响因子：
9
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Shang C;Qiao J;Guo H
转移前小生境是转移性肿瘤细胞在特定远端器官中定植的有利微环境。脂滴（LDs，也称为脂质体或脂肪体）已越来越多地被认为是肿瘤细胞、免疫细胞和其他基质细胞内富含脂质的功能动态细胞器，其与多种生物功能和人类疾病有关。此外，近年来，多项研究描述了LD在转移前壁龛发展中不可或缺的作用。这篇综述讨论了目前的证据有关的生物起源，组成和功能的LD相关的转移前生态位的以下特征：免疫抑制，炎症，血管生成/血管通透性，淋巴管生成，亲器官性，重编程。我们还讨论了LD在介导转移前小生境形成中的功能。LD作为新的抗转移治疗的标记物和靶点的潜力将被讨论。
The pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immune cells, and other stromal cells that are linked to diverse biological functions and human diseases. Moreover, in recent years, several studies have described the indispensable role of LDs in the development of pre-metastatic niches. This review discusses current evidence related to the biogenesis, composition, and functions of LDs related to the following characteristics of the pre-metastatic niche: immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, reprogramming. We also address the function of LDs in mediating pre-metastatic niche formation. The potential of LDs as markers and targets for novel antimetastatic therapies will be discussed.
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影响因子：
8
作者：
Chen XW;Yu TJ;Zhang J;Li Y;Chen HL;Yang GF;Yu W;Liu YZ;Liu XX;Duan CF;Tang HL;Qiu M;Wang CL;Zheng H;Yue J;Guo AM;Yang J
通讯作者：
Yang J
影响因子：
3.7
作者：
Boschi, Federico;Rizzatti, Vanni;Sbarbati, Andrea
通讯作者：
Sbarbati, Andrea
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
6.4
作者：
Carvalho, Marco A.;Zecchin, Karina G.;Graner, Edgard
通讯作者：
Graner, Edgard
溶血磷脂酰胆碱酰基转移酶2介导的脂质液滴生产支持结直肠癌的化学耐药性。
影响因子：
16.6
作者：
Cotte AK;Aires V;Fredon M;Limagne E;Derangère V;Thibaudin M;Humblin E;Scagliarini A;de Barros JP;Hillon P;Ghiringhelli F;Delmas D
通讯作者：
Delmas D