Comparison of the Effects of Hypertonic Saline and Crystalloid Infusions on Haemodynamic Parameters during Haemorrhagic Shock in Dogs
Comparison of the Effects of Hypertonic Saline and Crystalloid Infusions on Haemodynamic Parameters during Haemorrhagic Shock in Dogs
复制标题
高渗盐水与晶体输注对失血性休克犬血流动力学参数影响的比较
DOI：
10.1177/147323000102900607
复制
发表时间：
2001
影响因子：
1.6
通讯作者：
M. Gökben
中科院分区：
文献类型：
--
作者：
M. Us;S. Özkan;L. Oral;T. Oăuş;H. Acar;O. Çakir;Ö. Keskin;C. Top;M. Gökben
出血性休克是死亡的主要原因，经常伴随心脏干预。给予少量高渗盐溶液和晶体溶液可降低休克的严重程度和持续时间，并导致不良结局减少。在全身麻醉下，12只健康犬诱导低血压。30分钟后，犬接受高渗盐水溶液或乳酸林格氏溶液进行液体复苏。在两组中，在休克期间观察到血液动力学变量降低。复苏后，观察到血液动力学变量增加。在接受高渗盐水的犬中，这种增加持续时间更长。在两组中，复苏后红细胞压积和氧含量值降低，乳酸水平升高。在复苏过程中，乳酸水平下降。随着复苏，钠和渗透压升高，随后降低。总之，在出血性休克模型中，给予高渗盐溶液可更快地提供血液动力学稳定性和组织氧合。
Haemorrhagic shock, a leading cause of mortality, frequently accompanies cardiac interventions. The administration of small volumes of hypertonic saline solutions and crystalloid solutions may reduce the severity and duration of shock, and result in a decrease in adverse outcomes. Under general anaesthesia, hypotension was induced in 12 healthy dogs. After 30 min, dogs received either hypertonic saline solution or lactated Ringer's solution for fluid resuscitation. In both groups, decreases in haemodynamic variables were observed during the shock period. Following resuscitation, increases in haemodynamic variables were observed. This increase lasted longer in dogs receiving hypertonic saline. In both groups, haematocrit and oxygen content values decreased after resuscitation and lactate levels increased. During resuscitation, lactate levels decreased. Sodium and osmolarity increased with resuscitation, then subsequently decreased. In conclusion, in a model of haemorrhagic shock, the administration of hypertonic saline solutions provides haemodynamic stability and tissue oxygenation more rapidly.
低血容量出血高渗复苏中的动态液体再分配。
DOI：
10.1152/ajpheart.1988.255.3.h629
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Mazzoni,MC;Borgström,P;Arfors,KE;Intaglietta,M
通讯作者：
Intaglietta,M