Activity-based fluorescent reporters for monoamine oxidases in living cells
Activity-based fluorescent reporters for monoamine oxidases in living cells
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DOI：
10.1039/b713190a
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发表时间：
2007-01-01
影响因子：
4.9
通讯作者：
Chang, Christopher J.
中科院分区：
文献类型：
--
作者：
Albers, Aaron E.;Rawls, Katherine A.;Chang, Christopher J.
单胺氧化酶报告1和2(MR1和MR2)是底物依赖的活性探针，利用串联的胺氧化/β消除机制直接和特异地在体外和活细胞中检测MAO化学，而不需要额外的酶或其他激活试剂。
Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/beta-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagents.