SPECT imaging of dopamine and serotonin transporters with [123I]β-CIT. Binding kinetics in the human brain
SPECT imaging of dopamine and serotonin transporters with [123I]β-CIT. Binding kinetics in the human brain
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人脑中多巴胺和血清素转运蛋白与 [123I]β-CIT 结合动力学的 SPECT 成像。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Ivo Podreka
中科院分区：
文献类型：
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作者：
Thomas Brücke;Johannes Kornhuber;Peter Angelberger;Susanne Asenbaum;H. Frassine;Ivo Podreka
先前在非人类灵长类动物中进行的单光子发射计算机断层扫描（SPECT）研究表明，可卡因衍生物[123 I]-2-β-甲氧羰基-3-β-（4-碘苯基）-托烷（[123 I]β-CIT）标记纹状体中的多巴胺转运蛋白和下丘脑中脑区域中的5-羟色胺转运蛋白。本文报道了4例正常人和2例帕金森病患者脑内[123 I]β-CIT的局部动态摄取。在健康受试者中，纹状体活性缓慢增加，在注射后约20小时达到峰值。在下丘脑-中脑区，在约4小时观察到峰值活动，此后缓慢下降。在皮质和小脑区域观察到低活性。纹状体与小脑的比率在5小时后约为4，20小时后约为9。在2例原发性帕金森病患者中，纹状体活动明显减少，而下丘脑-中脑区域的活动仅轻度减少。在帕金森病患者中，皮质和小脑区域的摄取似乎没有变化。因此，在帕金森氏病中，纹状体与小脑的比率在20小时后降低至约2.5的值。这些初步的方法学研究表明，[123 I]β-CIT是一种有用的SPECT配体，用于研究多巴胺，也可能是5-羟色胺转运蛋白在活的人脑。
Single photon emission computerized tomography (SPECT) studies in non-human primates have previously shown that the cocaine derivative [123I]-2-β-carbomethoxy-3-β-(4-iodophenyl)-tropane ([123I]β-CIT) labels dopamine transporters in the striatum and serotonin transporters in the hypothalamusmidbrain area. Here, we report on the regional kinetic uptake of [123I]β-CIT in the brain of 4 normal volunteers and 2 patients with Parkinson's disease. In healthy subjects striatal activity increased slowly to reach peak values at about 20 hours post injection. In the hypothalamus-midbrain area peak activities were observed at about 4 hours with a slow decrease thereafter. Low activity was observed in cortical and cerebellar areas. The striatal to cerebellar ratio was about 4 after 5 hours and 9 after 20 hours. In 2 patients with idiopathic Parkinson's disease striatal activity was markedly decreased while the activity in hypothalamus-midbrain areas was only mildly diminished. Uptake into cortical and cerebellar areas appeared to be unchanged in Parkinson's disease. Consequently, in Parkinson's disease the striatal to cerebellar ratio was decreased to values around 2.5 after 20 hours. These preliminary methodological studies suggest that [123I]β-CIT is a useful SPECT ligand for studying dopamine and possibly also serotonin transporters in the living human brain.
[123I]-2 beta-甲甲氧基-3 beta-(4-碘苯基)托烷：大脑中单胺再摄取位点的高亲和力 SPECT 放射性示踪剂。
影响因子：
7.3
作者：
Neumeyer,JL;Wang,SY;Milius,RA;Baldwin,RM;Zea-Ponce,Y;Hoffer,PB;Sybirska,E;al-Tikriti,M;Charney,DS;Malison,RT
通讯作者：
Malison,RT