Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy.
Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy.
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DOI：
10.3389/fnins.2021.710004
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发表时间：
2021
影响因子：
4.3
通讯作者：
Yehuda R
中科院分区：
文献类型：
--
作者：
Lepow L;Morishita H;Yehuda R
随着迷幻化合物在精神病学中获得牵引力，有必要考虑主动机制来解释随机临床试验中观察到的效果。传统上，生物精神病学询问化合物如何影响疾病的因果途径以减轻症状，因此专注于药理学特性的分析。在迷幻剂辅助心理治疗（PAP）中，存在关于单独摄入迷幻剂是否被认为是临床结果的争论。一个问题是，药物和心理治疗干预如何共同导致神经生物学变化，这些变化是从创伤后应激障碍（PTSD）等疾病中恢复的基础。本文提供了一个框架，调查PAP的神经生物学基础外推模型用于解释如何药物干预可能会创建一个最佳的大脑状态，在此期间，环境输入具有持久的影响。具体来说，有发展的“关键”时期（CP）与环境输入的灵敏度，生物学特性在很大程度上是未知的。我们讨论了一个假设，迷幻剂可能会删除成人神经可塑性的刹车，诱导类似的神经发育的状态。在视觉系统中，在识别区分CP的生物条件和操纵活性成分方面都取得了进展，我们可能会重新开启成年期的关键时期。我们强调眼优势可塑性（ODP）在视觉系统中作为一个模型表征CP边缘系统相关的精神病学。一个CP框架可能有助于整合神经科学的调查与环境的影响，无论是在发展和PAP。
As psychedelic compounds gain traction in psychiatry, there is a need to consider the active mechanism to explain the effect observed in randomized clinical trials. Traditionally, biological psychiatry has asked how compounds affect the causal pathways of illness to reduce symptoms and therefore focus on analysis of the pharmacologic properties. In psychedelic-assisted psychotherapy (PAP), there is debate about whether ingestion of the psychedelic alone is thought to be responsible for the clinical outcome. A question arises how the medication and psychotherapeutic intervention together might lead to neurobiological changes that underlie recovery from illness such as post-traumatic stress disorder (PTSD). This paper offers a framework for investigating the neurobiological basis of PAP by extrapolating from models used to explain how a pharmacologic intervention might create an optimal brain state during which environmental input has enduring effects. Specifically, there are developmental “critical” periods (CP) with exquisite sensitivity to environmental input; the biological characteristics are largely unknown. We discuss a hypothesis that psychedelics may remove the brakes on adult neuroplasticity, inducing a state similar to that of neurodevelopment. In the visual system, progress has been made both in identifying the biological conditions which distinguishes the CP and in manipulating the active ingredients with the idea that we might pharmacologically reopen a critical period in adulthood. We highlight ocular dominance plasticity (ODP) in the visual system as a model for characterizing CP in limbic systems relevant to psychiatry. A CP framework may help to integrate the neuroscientific inquiry with the influence of the environment both in development and in PAP.
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影响因子：
25.8
作者：
Heifets BD;Malenka RC
通讯作者：
Malenka RC
影响因子：
64.8
作者：
Cameron LP;Tombari RJ;Lu J;Pell AJ;Hurley ZQ;Ehinger Y;Vargas MV;McCarroll MN;Taylor JC;Myers-Turnbull D;Liu T;Yaghoobi B;Laskowski LJ;Anderson EI;Zhang G;Viswanathan J;Brown BM;Tjia M;Dunlap LE;Rabow ZT;Fiehn O;Wulff H;McCorvy JD;Lein PJ;Kokel D;Ron D;Peters J;Zuo Y;Olson DE
通讯作者：
Olson DE
DOI：
10.1177/0269881117725915
发表时间：
2017-09
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Carhart-Harris RL;Nutt DJ
通讯作者：
Nutt DJ
影响因子：
64.5
作者：
Casarotto PC;Girych M;Fred SM;Kovaleva V;Moliner R;Enkavi G;Biojone C;Cannarozzo C;Sahu MP;Kaurinkoski K;Brunello CA;Steinzeig A;Winkel F;Patil S;Vestring S;Serchov T;Diniz CRAF;Laukkanen L;Cardon I;Antila H;Rog T;Piepponen TP;Bramham CR;Normann C;Lauri SE;Saarma M;Vattulainen I;Castrén E
通讯作者：
Castrén E
影响因子：
3.7
作者：
Branchi, Igor
通讯作者：
Branchi, Igor