Opiate involvement in contrast media-induced blood pressure changes.
Opiate involvement in contrast media-induced blood pressure changes.
复制标题
阿片类药物参与造影剂引起的血压变化。
DOI：
10.1097/00004424-198711000-00012
复制
发表时间：
1987
影响因子：
6.7
通讯作者：
Kido,DK
中科院分区：
文献类型：
--
作者：
Harnish,PP;Mukherji,M;Northington,FK;Kido,DK
静脉注射造影剂（CM）经常会改变血压（BP）。渗透压摩尔浓度起作用，但在相似（渗透）条件下变化的幅度甚至方向不同，表明其他机制的参与。用戊巴比妥麻醉的雄性Wistar大鼠通过尾静脉接受4 ml/kg的泛影葡胺钠、碘海醇或生理盐水，同时连续记录血压。其他组在泛影葡胺注射前5分钟用阿片拮抗剂纳洛酮（1 mg/kg，IV）或等体积的生理盐水进行预处理。用Student t检验比较BP变化。泛影葡胺组与对照组比较差异有统计学意义（P<. 0002）相对于盐水对照组，碘海醇没有增加血压。因此，泛影葡胺的增加显著大于碘海醇（P<. 00006）。生理盐水和纳洛酮预处理均未显著改变BP。生理盐水预处理没有改变泛影葡胺引起的血压显著升高。纳洛酮预处理可抑制泛影葡胺引起的血压升高，且显著低于生理盐水预处理（P<0.05）。0001）。基于这些和以前的结果，作者假设内源性阿片样物质的释放可能在静脉内CM引起的BP变化中起作用，并且选择性阿片受体阻滞剂纳洛酮可以预防CM引起的显著变化。
The intravenous administration of contrast media (CM) often alters blood pressure (BP). Osmolality plays a role, but the magnitude and even direction of change varies under similar (osmotic) conditions, indicating the involvement of other mechanisms. Male Wistar rats, anesthetized with pentobarbital, received sodium/meglumine diatrizoate, iohexol, or normal saline, 4 ml/kg, via a tail vein, while blood pressure was recorded continuously. Additional groups were pretreated with the opiate antagonist, naloxone (1 mg/kg, IV), or with an equal volume of normal saline 5 minutes prior to the diatrizoate injection. Comparisons of BP change were made with the Student's t-test. Diatrizoate caused a significant (P<. 0002) increase in BP relative to the saline control group, iohexol did not. Thus, the increase with diatrizoate was significantly greater than with iohexol (P<. 00006). Neither the saline nor naloxone pretreatment altered BP significantly. Saline pretreatment did not alter the significant increase in BP produced by the diatrizoate. However, the diatrizoate-induced increase in BP was prevented by the naloxone pretreatment and was significantly less than after the saline pretreatment (P<. 0001). Based on these and previous results, the authors hypothesize that release of endogenous opioids may play a role in BP changes caused by intravenous CM and that significant CM-induced changes may be prevented pharmacologically with the selective opiate blocker, naloxone.