No association between allelic variants of HOXA1/HOXB1 and autism
No association between allelic variants of HOXA1/HOXB1 and autism
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DOI：
10.1002/ajmg.b.20094
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发表时间：
2004-01-01
影响因子：
2.8
通讯作者：
Gill, M
中科院分区：
文献类型：
--
作者：
Gallagher, L;Hawi, Z;Gill, M
最近的两项研究报告了 HOXA1 基因变异与自闭症相关的相互矛盾的发现。为了尝试解决研究结果中的冲突，我们对 78 个爱尔兰家庭进行了一项已报告 DNA 变异的关联研究。我们没有发现这些变异与自闭症之间存在统计学上的显着关联。同样，没有证据表明变异会优先从任一性别的父母传给受影响的后代。我们还报告了 HOXB1 变异的阴性结果。我们得出结论，HOXA1/B1 不太可能是我们样本中自闭症的易感基因。 (C) 2003 Wiley-Liss, Inc.
Two recent studies have reported conflicting findings of association of a variant in the HOXA1 gene and autism. To try to resolve the conflict in findings, we conducted an association study in 78 Irish families of the reported DNA variants. We did not find statistically significant association between the variants and autism. Similarly there was no evidence of preferential transmission of variants from parent of either sex to affected offspring. We also report negative findings for HOXB1 variants. We conclude that the HOXA1/B1 are unlikely to be the susceptibility genes for autism in our sample. (C) 2003 Wiley-Liss, Inc.