MR-Based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution
MR-Based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution
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DOI：
10.1097/00004647-199607000-00016
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发表时间：
1996-07-01
影响因子：
6.3
通讯作者：
Frost, JJ
中科院分区：
文献类型：
--
作者：
Meltzer, CC;Zubieta, JK;Frost, JJ
部分体积和混合组织采样误差会导致定量正电子发射断层扫描（PET）测量的显著不准确。我们以前描述了一种方法，纠正PET数据的影响，部分体积平均灰质（GM）定量，但是，这种方法可能不完全纠正GM结构时，局部组织浓度是高度异质性的。我们已经扩展了这个三分区算法，包括第四个分区：GM感兴趣体积（VOI），可以描绘在磁共振（MR）成像，计算机模拟PET图像创建的人类MR数据显示的错误高达120%的分配活动值在未校正的数据在小的大脑结构。四室校正实现了大范围的编码活动，如杏仁核，尾状核和丘脑的GM VOI的完全恢复。在实际PET采集的琼脂糖脑体模中进行进一步验证。还在健康老年人受试者中采集的[F-18]氟脱氧葡萄糖和[C-11]卡芬太尼PET数据中实施了该部分体积校正方法。这种新开发的基于MR的部分体积校正算法允许准确测定特定结构中的真实放射性浓度，该特定结构可通过考虑GM放射性异质性的影响由MR定义。
Partial volume and mixed tissue sampling errors can cause significant inaccuracy in quantitative positron emission tomographic (PET) measurements. We previously described a method of correcting PET data for the effects of partial volume averaging on gray matter (GM) quantitation; however, this method may incompletely correct GM structures when local tissue concentrations are highly heterogeneous. We have extended this three-compartment algorithm to include a fourth compartment: a GM volume of interest (VOI) that can be delineated on magnetic resonance (MR) imaging, Computer simulations of PET images created from human MR data demonstrated errors of up to 120% in assigned activity values in small brain structures in uncorrected data. Four-compartment correction achieved full recovery of a wide range of coded activity in GM VOIs such as the amygdala, caudate, and thalamus. Further validation was performed in an agarose brain phantom in actual PET acquisitions. Implementation of this partial volume correction approach in [F-18]fluorodeoxyglucose and [C-11]carfentanil PET data acquired in a healthy elderly human subject was also performed. This newly developed MR-based partial volume correction algorithm permits the accurate determination of the true radioactivity concentration in specific structures that can be defined by MR by accounting for the influence of heterogeneity of GM radioactivity.